• 主页
  • 查找结果
  • Developing ligands for palladium(II)-catalyzed C-H functionalization: intimate dialogue between ligand and substrate.

Developing ligands for palladium(II)-catalyzed C-H functionalization: intimate dialogue between ligand and substrate.

The Journal of organic chemistry (2013-04-10)
Keary M Engle, Jin-Quan Yu
摘要

Homogeneous transition-metal-catalyzed reactions are indispensable to all facets of modern chemical synthesis. It is thus difficult to imagine that for much of the early 20th century, the reactivity and selectivity of all known homogeneous metal catalysts paled in comparison to their heterogeneous and biological counterparts. In the intervening decades, advances in ligand design bridged this divide, such that today some of the most demanding bond-forming events are mediated by ligand-supported homogeneous metal species. While ligand design has propelled many areas of homogeneous catalysis, in the field of Pd(II)-catalyzed C-H functionalization, suitable ligand scaffolds are lacking, which has hampered the development of broadly practical transformations based on C-H functionalization logic. In this Perspective, we offer an account of our research employing three ligand scaffolds, mono-N-protected amino acids, 2,6-disubstituted pyridines, and 2,2'-bipyridines, to address challenges posed by several synthetically versatile substrate classes. Drawing on this work, we discuss principles of ligand design, such as the need to match a ligand to a particular substrate class, and how ligand traits such as tunability and modularity can be advantageous in reaction discovery.

材料
货号
品牌
产品描述

Sigma-Aldrich
钯, powder, <1 μm, ≥99.9% trace metals basis
Sigma-Aldrich
钯, powder, 99.995% trace metals basis
Sigma-Aldrich
钯黑, surface area 40-60 m2/g, 99.95% trace metals basis
Sigma-Aldrich
钯, granular, 99.99% trace metals basis
Sigma-Aldrich
钯, nanopowder, <25 nm particle size (TEM), ≥99.5%
Sigma-Aldrich
钯, foil, thickness 0.025 mm, 99.9% trace metals basis
Sigma-Aldrich
钯, wire, diam. 0.5 mm, 99.9% trace metals basis
Sigma-Aldrich
钯, wire, diam. 1.0 mm, 99.9% trace metals basis
Sigma-Aldrich
钯, foil, thickness 0.05 mm, 99.9% trace metals basis
Sigma-Aldrich
钯, foil, thickness 0.5 mm, 99.9% trace metals basis
钯, foil, 25x25mm, thickness 0.25mm, as rolled, 99.95%
Sigma-Aldrich
钯, foil, thickness 0.25 mm, 99.98% trace metals basis
Sigma-Aldrich
钯, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.95% trace metals basis
钯, foil, 50x50mm, thickness 0.1mm, as rolled, 99.95%
钯, foil, light tested, 25x25mm, thickness 0.006mm, 99.95%
钯, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.95%
钯, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.99+%
钯, foil, light tested, 25x25mm, thickness 0.03mm, as rolled, 99.95%
钯, foil, light tested, 25x25mm, thickness 0.047mm, as rolled, 99.95%
钯, foil, light tested, 25x25mm, thickness 0.075mm, as rolled, 99.95%
钯, foil, light tested, 50x50mm, thickness 0.025mm, as rolled, 99.95%
钯, foil, light tested, 50x50mm, thickness 0.025mm, as rolled, 99.99+%
钯, foil, light tested, 50x50mm, thickness 0.03mm, as rolled, 99.95%
钯, foil, light tested, 50x50mm, thickness 0.047mm, as rolled, 99.95%
钯, foil, light tested, 50x50mm, thickness 0.075mm, as rolled, 99.95%
钯, foil, not light tested, 100x100mm, thickness 0.004mm, 99.95%
钯, foil, not light tested, 100x100mm, thickness 0.005mm, 99.95%
钯, foil, not light tested, 100x100mm, thickness 0.008mm, 99.95%
钯, foil, not light tested, 100x100mm, thickness 0.0125mm, 99.95%
钯, foil, not light tested, 100x100mm, thickness 0.025mm, as rolled, 99.95%

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。