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  • Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)
George Psomas, Dimitris P Kessissoglou
摘要

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

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钴, powder, <150 μm, ≥99.9% trace metals basis
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镍, foil, thickness 0.125 mm, ≥99.9%
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镍, foil, thickness 0.5 mm, 99.98% trace metals basis
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镍, wire, diam. 0.25 mm, ≥99.9%
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钴, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%
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镍, foil, thickness 0.1 mm, 99.98% trace metals basis
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钴, granular, 99.99% trace metals basis
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镍, wire, diam. 0.5 mm, ≥99.9% trace metals basis
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钴, foil, thickness 0.1 mm, 99.95% trace metals basis
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镍, wire, diam. 0.5 mm, ≥99.99% trace metals basis
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钴, pieces, 99.5% trace metals basis
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钴, wire, diam. 1.0 mm, 99.995% trace metals basis
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镍, rod, diam. 6.35 mm, ≥99.99% trace metals basis
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镍, foil, thickness 0.25 mm, 99.995% trace metals basis
镍, mesh, 100x250mm, nominal aperture 0.73mm, wire diameter 0.25mm, 26x26 wires/inch, open area 55%, plain weave mesh, 99%
镍, wire reel, 20m, diameter 0.025mm, as drawn, 99.98%
镍, wire reel, 10m, diameter 0.01mm, as drawn, 99.98%
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钴, foil, thickness 0.25 mm, ≥99.99% trace metals basis
镍, rod, 100mm, diameter 16mm, 99.99+%
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镍, rod, 100mm, diameter 3.0mm, 99%
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