Merck

The role of zinc and copper in autism spectrum disorders.

Acta neurobiologiae experimentalis (2013-07-05)
Geir Bjorklund
ABSTRACT

Autism spectrum disorders (ASDs) are a group of developmental disabilities that can cause significant social, communication and behavioral challenges. Several studies have suggested a disturbance in the copper (Cu) and zinc (Zn) metabolism in ASDs. Zinc deficiency, excess Cu levels, and low Zn/Cu ratio are common in children diagnosed with an ASD. The literature also suggests that mercury accumulation may occur as a cause or consequence of metallothionein (MT) dysfunction in children diagnosed with an ASD, which may be one of the causes of Zn deficiency. MTs are proteins with important functions in metal metabolism and protection. Zinc and Cu bind to and participate in the control of the synthesis of MT proteins. Studies indicate that the GABAergic system may be involved in ASDs, and that Zn and Cu may play a role in this system.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
铜, powder, <425 μm, 99.5% trace metals basis
Sigma-Aldrich
铜, wire, diam. 1.0 mm, ≥99.9%
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铜, foil, thickness 0.25 mm, 99.98% trace metals basis
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铜, powder, 99.999% trace metals basis
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铜, nanopowder, 60-80 nm particle size (SAXS), ≥99.5% trace metals basis
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铜, nanopowder, 40-60 nm particle size (SAXS), ≥99.5% trace metals basis
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铜, foil, ≥99.8% (complexometric)
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铜, foil, thickness 0.025 mm, 99.98% trace metals basis
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铜, powder, <75 μm, 99%
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铜, powder (spheroidal), 10-25 μm, 98%
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铜, turnings, purum p.a., ≥99.0%
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铜, foil, thickness 1.0 mm, 99.999% trace metals basis
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铜, powder (dendritic), <45 μm, 99.7% trace metals basis
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铜, wire, diam. 0.25 mm, 99.999% trace metals basis
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铜, foil, thickness 0.5 mm, 99.98% trace metals basis
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铜, spherical shot, −20-+30 mesh, ≥99.5% trace metals basis
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铜, bars (random sizes), ≥99.999% trace metals basis
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铜, electrolytic, Analytical Reagent, reag. Ph. Eur., ≥99.9% (complexometric), wire
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铜, rod, diam. 11 mm, 99.9999% trace metals basis
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铜, beads, 2-8 mm, ≥99.99% trace metals basis
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铜, beads, 2-8 mm, 99.9995% trace metals basis
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铜, shot, −3-+14 mesh, 99%
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铜, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.95% trace metals basis
铜, foil, 150x150mm, thickness 0.1mm, annealed, 99.95+%
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铜, wire, diam. 2.0 mm, 99.999% trace metals basis
铜, mesh, 100x100mm, nominal aperture 0.14mm, thickness 0.25mm, wire diameter 0.115mm, 100x100 wires/inch, open area 30.3%, plain weave mesh
铜, mesh, 130x130mm, nominal aperture 0.2mm, thickness 0.004mm, wire diameter 0.0125mm, 118 wires/inch, open area 88%, electro-formed mesh
铜, foil, 100x100mm, thickness 0.125mm, hard, 99.95+%