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Protein tyrosine phosphatases: structure, function, and implication in human disease.

Methods in molecular biology (Clifton, N.J.) (2013-07-19)
Lutz Tautz, David A Critton, Stefan Grotegut
ABSTRACT

Protein tyrosine phosphorylation is a key regulatory mechanism in eukaryotic cell physiology. Aberrant expression or function of protein tyrosine kinases and protein tyrosine phosphatases can lead to serious human diseases, including cancer, diabetes, as well as cardiovascular, infectious, autoimmune, and neuropsychiatric disorders. Here, we give an overview of the protein tyrosine phosphatase superfamily with its over 100 members in humans. We review their structure, function, and implications in human diseases, and discuss their potential as novel drug targets, as well as current challenges and possible solutions to developing therapeutics based on these enzymes.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
L-酪氨酸, reagent grade, ≥98% (HPLC)
SAFC
L-酪氨酸
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L-酪氨酸, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 99.0-101.0%
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L-酪氨酸, BioUltra, ≥99.0% (NT)
Supelco
L-酪氨酸, Pharmaceutical Secondary Standard; Certified Reference Material
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USP
L-酪氨酸, United States Pharmacopeia (USP) Reference Standard
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