Merck

Ocular manifestations of monoclonal copper-binding immunoglobulin.

Survey of ophthalmology (2013-10-12)
Sejal Shah, Edgar M Espana, Curtis E Margo
ABSTRACT

The dense accumulation of copper in Descemet membrane and lens capsule is the characteristic manifestation of a circulating monoclonal antibody with strong affinity for copper. The overproduction of this monoclonal immunoglobulin may be associated with either multiple myeloma or a benign monoclonal gammopathy. Despite prolonged exposure to elevated serum copper, no other tissues in the body are adversely affected by this redox metal. We describe the clinical and pathological findings in a 46-year-old woman with this disorder.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
铜, powder, <425 μm, 99.5% trace metals basis
Sigma-Aldrich
铜, wire, diam. 1.0 mm, ≥99.9%
Sigma-Aldrich
铜, foil, thickness 0.25 mm, 99.98% trace metals basis
Sigma-Aldrich
铜, powder, 99.999% trace metals basis
Sigma-Aldrich
铜, nanopowder, 60-80 nm particle size (SAXS), ≥99.5% trace metals basis
Sigma-Aldrich
铜, ACS reagent, granular, 10-40 mesh, ≥99.90%
Sigma-Aldrich
铜, foil, ≥99.8% (complexometric)
Sigma-Aldrich
铜, foil, thickness 0.025 mm, 99.98% trace metals basis
Sigma-Aldrich
铜, powder, <75 μm, 99%
Sigma-Aldrich
铜, powder (spheroidal), 10-25 μm, 98%
Sigma-Aldrich
铜, turnings, purum p.a., ≥99.0%
Sigma-Aldrich
铜, foil, thickness 1.0 mm, 99.999% trace metals basis
Sigma-Aldrich
铜, powder (dendritic), <45 μm, 99.7% trace metals basis
Sigma-Aldrich
铜, wire, diam. 0.25 mm, 99.999% trace metals basis
Sigma-Aldrich
铜, foil, thickness 0.5 mm, 99.98% trace metals basis
Sigma-Aldrich
铜, spherical shot, −20-+30 mesh, ≥99.5% trace metals basis
Sigma-Aldrich
铜, bars (random sizes), ≥99.999% trace metals basis
Sigma-Aldrich
铜, wire, diam. 0.64 mm, 99.995% trace metals basis
Sigma-Aldrich
铜, electrolytic, Analytical Reagent, reag. Ph. Eur., ≥99.9% (complexometric), wire
Sigma-Aldrich
铜, rod, diam. 11 mm, 99.9999% trace metals basis
Sigma-Aldrich
铜, beads, 2-8 mm, ≥99.99% trace metals basis
Sigma-Aldrich
铜, beads, 2-8 mm, 99.9995% trace metals basis
Sigma-Aldrich
铜, shot, −3-+14 mesh, 99%
Sigma-Aldrich
铜, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.95% trace metals basis
铜, foil, 150x150mm, thickness 0.1mm, annealed, 99.95+%
Sigma-Aldrich
铜, wire, diam. 2.0 mm, 99.999% trace metals basis
铜, mesh, 100x100mm, nominal aperture 0.14mm, thickness 0.25mm, wire diameter 0.115mm, 100x100 wires/inch, open area 30.3%, plain weave mesh
铜, mesh, 130x130mm, nominal aperture 0.2mm, thickness 0.004mm, wire diameter 0.0125mm, 118 wires/inch, open area 88%, electro-formed mesh
铜, foil, 100x100mm, thickness 0.125mm, hard, 99.95+%
铜, rod, 100mm, diameter 2.0mm, as drawn, 99.99+%