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  • Gold-catalyzed formation of heterocycles - an enabling new technology for medicinal chemistry.

Gold-catalyzed formation of heterocycles - an enabling new technology for medicinal chemistry.

Drug discovery today. Technologies (2013-09-21)
Hong C Shen, Thomas H Graham
摘要

Gold-catalyzed transformations allow efficient access to a wide scope of heterocyclic structures that serve as building blocks and pharmacophores in medicinal chemistry. Compared with other transition metal and Lewis acid catalysis, gold catalysis presents mechanistic divergence, excellent functional group tolerance and/or operational advantages. Emergent applications of gold catalysis have played a key role in the synthesis of biologically active molecules including a drug candidate.

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