Merck

Iron homeostasis in breast cancer.

Cancer letters (2014-02-04)
Oriana Marques, Berta Martins da Silva, Graça Porto, Carlos Lopes
ABSTRACT

Iron is an essential element and a critical component of molecules involved in energy production, cell cycle and intermediate metabolism. However, the same characteristic chemistry that makes it so biologically versatile may lead to iron-associated toxicity as a consequence of increased oxidative stress. The fact that free iron accumulates with age and generates ROS led to the hypothesis that it could be involved in the etiogenesis of several chronic diseases. Iron has been consistently linked to carcinogenesis, either through persistent failure in the redox balance or due to its critical role in cellular proliferation. Several reports have given evidence that alterations in the import, export and storage of cellular iron may contribute to breast cancer development, behavior and recurrence. In this review, we summarize the basic mechanisms of systemic and cellular iron regulation and highlight the findings that link their deregulation with breast cancer. To conclude, progresses in iron chelation therapy in breast cancer, as a tool to fight chemotherapy resistance, are also reviewed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
铁, ≥99%, reduced, powder (fine)
Sigma-Aldrich
羰基铁, ≥97% Fe basis
Sigma-Aldrich
铁, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)
Sigma-Aldrich
铁, granular, 10-40 mesh, >99.99% trace metals basis
Sigma-Aldrich
铁, foil, thickness 0.1 mm, ≥99.9% trace metals basis
Sigma-Aldrich
铁, chips, 99.98% trace metals basis
Sigma-Aldrich
铁, foil, thickness 0.25 mm, ≥99.99% trace metals basis
Sigma-Aldrich
铁, wire, diam. 1.0 mm, ≥99.9% trace metals basis
Sigma-Aldrich
铁, carbon coated magnetic, nanopowder, 25 nm avg. part. size, 99.5% trace metals basis
Sigma-Aldrich
铁, wire, diam. 0.5 mm, ≥99.9% trace metals basis
铁, foil, 300x300mm, thickness 0.1mm, hard, 99.5%
Sigma-Aldrich
铁, wire, diam. 1.0 mm, ≥99.99% trace metals basis
铁, rod, 200mm, diameter 2.0mm, as drawn, 99.99+%
铁, rod, 50mm, diameter 5.0mm, as drawn, 99.99+%
铁, wire reel, 5m, diameter 0.025mm, as drawn, 99.99+%
铁, foil, 100x100mm, thickness 0.25mm, hard, 99.5%
铁, foil, 300x300mm, thickness 0.38mm, hard, 99.5%
铁, foil, 100x100mm, thickness 1.5mm, as rolled, 99.5%
铁, foil, 10mm disks, thickness 0.01mm, 99.85%
铁, foil, 10mm disks, thickness 0.01mm, 99.99+%
铁, foil, 10mm disks, thickness 0.020mm, 99.85%
铁, foil, 10mm disks, thickness 0.025mm, as rolled, 99.99+%
铁, foil, 10mm disks, thickness 0.025mm, hard, 99.5%
铁, foil, 10mm disks, thickness 0.038mm, hard, 99.5%
铁, foil, 10mm disks, thickness 0.05mm, as rolled, 99.99+%
铁, foil, 10mm disks, thickness 0.05mm, hard, 99.5%
铁, foil, 10mm disks, thickness 0.075mm, as rolled, 99.99+%
铁, foil, 10mm disks, thickness 0.075mm, hard, 99.5%
铁, foil, 10mm disks, thickness 0.125mm, as rolled, 99.99+%
铁, foil, 10mm disks, thickness 0.125mm, hard, 99.5%