Merck
  • 主页
  • 查找结果
  • The cytotoxic and genotoxic effects of metalaxy-M on earthworms (Eisenia fetida).

The cytotoxic and genotoxic effects of metalaxy-M on earthworms (Eisenia fetida).

Environmental toxicology and chemistry (2014-07-22)
Tong Liu, Lusheng Zhu, Yingnan Han, Jinhua Wang, Jun Wang, Yan Zhao
摘要

As the main optical isomer of metalaxyl, metalaxyl-M has been widely used worldwide in recent years because of its notable effect on the prevention and control of crop diseases. Together with the toxicity and degradation of metalaxyl-M, the chemical has attracted the attention of researchers. The present study examined the toxic effects of metalaxyl-M on earthworms at 0 mg kg(-1) , 0.1 mg kg(-1) , 1 mg kg(-1) , and 3 mg kg(-1) on days 7, 14, 21 and 28 after exposure. The results showed that metalaxyl-M could cause an obvious increase in the production of reactive oxygen species (ROS) when the concentration was higher than 0.1 mg kg(-1) , which led to lipid peroxidation in earthworms. Metalaxyl-M can induce DNA damage in earthworms, and the level of DNA damage markedly increased with increasing the concentration of metalaxyl-M. Metalaxyl-M also has a serious influence on the activities of antioxidant enzymes, which results in irreversible oxidative damage in cells. The changes of these indicators all indicated that metalaxyl-M may cause cytotoxic and genotoxic effects on earthworms.

材料
货号
品牌
产品描述

Sigma-Aldrich
L-丙氨酸, ≥98% (TLC)
Sigma-Aldrich
L-丙氨酸, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
L-丙氨酸, BioUltra, ≥99.5% (NT)
Supelco
精甲霜灵, PESTANAL®, analytical standard
Supelco
甲霜灵, PESTANAL®, analytical standard
Sigma-Aldrich
L-丙氨酸, ≥99%
Supelco
L-丙氨酸, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
L-丙氨酸, ≥99.0% (NT)
丙氨酸, European Pharmacopoeia (EP) Reference Standard
Supelco
L-丙氨酸, certified reference material, TraceCERT®
甲霜灵, analytical standard
Sigma-Aldrich
L-Alanine-12C3, 99.9 atom % 12C