90Sr content in 90Y-labeled SIR-spheres and Zevalin.

Health physics (2014-10-02)
John Metyko, William Erwin, John Poston, Sandra Jimenez
摘要

Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product. TheraSphere 90Y is produced in a nuclear reactor which results in a large number of impurities, most notably 88Y and 91Y. Product information sheets reference these impurities with specific limits given. These limits represent a tiny fraction of the total product activity, and in the case of TheraSphere and SIR-Spheres gamma-emitting impurities, this has been verified in the literature. An analysis of 90Sr impurities in SIR-Spheres and Zevalin is presented in this paper. Impurity quantities were found to be within the vendors’ documented limits.

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Sigma-Aldrich
锗, powder, −100 mesh, ≥99.999% trace metals basis
Sigma-Aldrich
锗, powder, −100 mesh, ≥99.99% trace metals basis
Sigma-Aldrich
锗, chips, 99.999% trace metals basis
锗, disks, 15mm, thickness 1.0mm, polycrystalline, 100%
锗, sheet, 50x50mm, thickness 1.0mm, polycrystalline, 99.999%
锗, disks, 20mm, thickness 1.0mm, single crystal, 100%
锗, microfoil, 25x25mm, thinness 0.25μm, specific density 166.3μg/cm2, 6 micron aluminum permanent support, 100%
锗, microfoil, 25x25mm, thinness 0.5μm, specific density 333μg/cm2, 6 micron aluminum permanent support, 100%
锗, microfoil, 50x50mm, thinness 0.25μm, specific density 166.3μg/cm2, 6 micron aluminum permanent support, 100%
锗, rod, 25mm, diameter 2.0mm, polycrystalline, n-type, 99.999%
锗, rod, 25mm, diameter 5mm, polycrystalline, n-type, 99.999%
锗, rod, 50mm, diameter 5mm, polycrystalline, n-type, 99.999%
锗, rod, 6mm, diameter 6.0mm, single crystal, 100%
锗, sheet, 10x10mm, thickness 0.25mm, polycrystalline, 99.999%
锗, sheet, 10x10mm, thickness 0.5mm, single crystal, -111, 100%
锗, sheet, 10x10mm, thickness 0.6mm, single crystal, -111, 100%
锗, sheet, 25x25mm, thickness 1.0mm, polycrystalline, 99.999%
锗, sheet, 25x25mm, thickness 1.0mm, single crystal, 99.999%
锗, sheet, 25x25mm, thickness 3.0mm, polycrystalline, 99.999%
锗, sheet, 4x4mm, thickness 0.05mm, polycrystalline, 99.999%
锗, sheet, 50x50mm, thickness 0.5mm, single crystal, 99.999%
锗, sheet, 50x50mm, thickness 3.0mm, polycrystalline, 99.999%
锗, sheet, 6x6mm, thickness 1.0mm, polycrystalline, 99.999%
锗, sheet, 7x24mm, thickness 1.0mm, polycrystalline, 99.999%
Sigma-Aldrich
锗, chips, 99.999% trace metals basis