Merck
  • 主页
  • 查找结果
  • A histological comparison of 50% and 70% glycolic acid peels using solutions with various pHs.

A histological comparison of 50% and 70% glycolic acid peels using solutions with various pHs.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (1996-05-01)
F F Becker, F P Langford, M G Rubin, P Speelman
摘要

Seventy percent glycolic acid solutions are being commonly used as superficial chemical peeling agents. The pH of these solutions ranges from 0.08 to 2.75. The histologic effects of these various pH solutions on human skin have not been studied. The histologic effects of several commercially available glycolic acid solutions at various pHs were examined. Test areas of seven glycolic acid solutions were applied to facial skin of two patients. The skin was not prepped for a peel prior to the application of the acid. The solution was left in place for 30 minutes, then neutralized. After 48 hours, a 2-mm punch biopsy was performed and examined histologically. The peeling solutions with a pH below 2 demonstrated the potential to induce crusting and necrosis, which was not seen with the partially neutralized solutions with a pH above 2. The higher concentration acids (70%) created more tissue damage than the lower concentration (50%) when comparing solutions with free acid. This study demonstrates that chemical peeling with a 70% free glycolic acid creates more tissue damage than a free glycolic acid. When using a 70% glycolic acid solution, the lower pH products (below pH 2) create more necrosis than the partially neutralized products with a pH above 2. At this time there is no evidence that creating necrosis leads to a more favorable result of the peel. Therefore, the use of partially neutralized glycolic acid solutions seems prudent, since they have a better safety profile than low pH solutions, which contain only free glycolic acid.

材料
货号
品牌
产品描述

Sigma-Aldrich
羟基乙酸, ReagentPlus®, 99%
Sigma-Aldrich
乙醇酸 溶液, technical grade, 70 wt. % in H2O
Sigma-Aldrich
乙醇酸 溶液, high purity, 70 wt. % in H2O