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  • Circulating immune/inflammation markers in Chinese workers occupationally exposed to formaldehyde.

Circulating immune/inflammation markers in Chinese workers occupationally exposed to formaldehyde.

Carcinogenesis (2015-04-25)
Wei Jie Seow, Luoping Zhang, Roel Vermeulen, Xiaojiang Tang, Wei Hu, Bryan A Bassig, Zhiying Ji, Meredith S Shiels, Troy J Kemp, Min Shen, Chuangyi Qiu, Boris Reiss, Laura E Beane Freeman, Aaron Blair, Christopher Kim, Weihong Guo, Cuiju Wen, Laiyu Li, Ligia A Pinto, Hanlin Huang, Martyn T Smith, Allan Hildesheim, Nathaniel Rothman, Qing Lan
摘要

Formaldehyde has been classified as a human myeloid leukemogen. However, the mechanistic basis for this association is still debated. We aimed to evaluate whether circulating immune/inflammation markers were altered in workers occupationally exposed to formaldehyde. Using a multiplexed bead-based assay, we measured serum levels of 38 immune/inflammation markers in a cross-sectional study of 43 formaldehyde-exposed and 51 unexposed factory workers in Guangdong, China. Linear regression models adjusting for potential confounders were used to compare marker levels in exposed and unexposed workers. We found significantly lower circulating levels of two markers among exposed factory workers compared with unexposed controls that remained significant after adjusting for potential confounders and multiple comparisons using a false discovery rate of 10%, including chemokine (C-X-C motif) ligand 11 (36.2 pg/ml in exposed versus 48.4 pg/ml in controls, P = 0.0008) and thymus and activation regulated chemokine (52.7 pg/ml in exposed versus 75.0 pg/ml in controls, P = 0.0028), suggesting immunosuppression among formaldehyde-exposed workers. Our findings are consistent with recently emerging understanding that immunosuppression might be associated with myeloid diseases. These findings, if replicated in a larger study, may provide insights into the mechanisms by which formaldehyde promotes leukemogenesis.

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Sigma-Aldrich
甲醛 溶液, ACS reagent, 37 wt. % in H2O, contains 10-15% Methanol as stabilizer (to prevent polymerization)
Sigma-Aldrich
甲醛 溶液, for molecular biology, 36.5-38% in H2O
Sigma-Aldrich
甲醛 溶液, for molecular biology, BioReagent, ≥36.0% in H2O (T)
Sigma-Aldrich
甲醛 溶液, meets analytical specification of USP, ≥34.5 wt. %
Sigma-Aldrich
甲醛-12C 溶液, 20% in H2O, 99.9 atom % 12C