Merck

Blood Typing

Blood typing reagents

Blood typing (also known as blood grouping) is a process of classifying blood based on the detection of antigens present on the surface of red blood cells (RBCs). The correct determination of the blood type of donors and patients is critical for the safe transfusion or transplantation of life-saving blood, blood components, or transplanted organs and tissues. Blood typing consists of using highly regulated, standardized, type-specific reagents or devices in tests with blood samples.

The International Society of Blood Transfusion (ISBT) recognizes thirty-nine major human blood typing systems for the detection of common and rare blood group variants, but the most common are ABO and Rh blood grouping systems. The basic principle of blood typing involves observation of a simple antigen-antibody reaction leading to hemagglutination or clumping of RBCs. 


The International Society of Blood Transfusion (ISBT) recognizes thirty-nine major human blood typing systems for the detection of common and rare blood group variants, but the most common are ABO and Rh blood grouping systems. The basic principle of blood typing involves observation of a simple antigen-antibody reaction leading to hemagglutination or clumping of RBCs. 

In the ABO system, the phenotype of an individual is usually determined by the hemagglutination reactions of the individual’s RBCs with Anti-A, Anti-B, and Anti-AB antisera (forward grouping). Lack of hemagglutination demonstrates the absence of the specific antigen, signifying a negative test. In testing blood samples from adults, confirmation of the ABO blood group can be provided by the reactions of the individual’s serum with standard A and B red cell suspensions (reverse grouping).

Blood grouping reagents and devices are highly regulated in all markets because the test results do not provide a diagnostic outcome, rather a therapeutic one. The results determine which donor blood, blood products or transplant tissues will be given to a patient. The development and manufacturing of regulated blood typing reagents and devices rely on the quality, consistency, and reliability of the constituent critical antibody raw materials, and ancillary chemicals and components. 

Blood Typing Products 

We offer finished reagents and raw materials for blood typing. Please contact us to learn more.

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Featured Categories

Blood Typing

Blood Typing

Blood Typing Solutions: Discover a broad range of standardized reagents and intermediates. Fostering creativity in blood typing product development.

Blood Typing Finished Reagents

Blood Typing Finished Reagents

Compliance-Ready Reagents: Explore our extensive range of European Directive 98/79/EC compliant reagents, available in various options to suit your needs.

Blood Typing Intermediates (FFMU)

Blood Typing Intermediates (FFMU)

Enhance production using standardized blood typing intermediates. Utilize cell culture supernatants with human/murine monoclonal antibodies for reagents & devices.


Featured Articles

  • Case Study: OEM Blood Typing

    A Blood Typing company was going through the process of expanding its portfolio of blood typing platform assays to further penetrate the market.

  • Brochure: Blood Typing Monoclonal Antibodies FFMU

    Merck is one of the leading providers of monoclonal antibodies to the blood typing market. Our large portfolio of standardized antibody intermediates for further manufacturing use allows manufacturers to create and manufacture a wide variety of blood typing reagents and devices.

  • Brochure: BIOSCOT® Blood Typing Monoclonal Reagents

    The BIOSCOT® name is globally synonymous with quality & Merck is one of the leading providers of monoclonal antibodies for the blood typing market. We offer the largest portfolio of human IgM monoclonal antibodies available today.

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