Merck

Closed Processing for Biomanufacturing

Closed Processing

The facility of the future will require transformation in how biologics are developed and manufactured. Closed processing mitigates contamination and safety risks, maximizes new and existing facility and asset utilization, while enabling sustainable multi-modal manufacturing. With closed processing costly cleanroom and environmental control measures are reduced without compromising product quality. Simplified space design, smaller cleanroom footprints, and increased operational flexibility allow for dramatic cost savings and future-readiness, today.

Operators in a closed processing CNC space

Close your process. Open your possibilities.

With closed processing, you can:

  • Mitigate contamination and safety risks
  • Reduce costly and environmentally demanding cleanroom control measures without compromising product quality
  • Enable connected and continuous process manufacturing
  • Maximize operational flexibility
  • Enable sustainable multi-modal manufacturing

Value drivers & benefits of closed bioprocessing

Microbe 47% reduction in contamination risk  
Microbe 81% reduction in gowning costs
Microbe 47% reduction in labor time due to reduced gowning, room cleaning, and equipment sanitization  
Microbe Up to 53% reduction in environmental monitoring
Microbe Up to 65% reduction in energy consumption

Related Podcast

Putting Biologics on the Fast Lane Podcast
Putting Biologics on the Fast Lane Podcast

Tune in & enter the world of Bioprocessing 4.0 with Merrilee Whitney, Chris Hwang and Kelvin Lee. In this podcast we discuss how to accelerate the production of biologics to a rapid pace. 


Related Webinars

Webinar on the benefits of single use closed processing for biopharmaceutical manufacturing
Closed Concept for Biopharmaceutical Manufacturing Webinar

Uncover the benefits and challenges associated with closed processing and learn how innovations in closed single-use systems are driving greater manufacturing efficiency.

Single-use tangential flow filtration for closed processing webinar
Single-Use Tangential Flow Filtration for Closed Processing Webinar

In this webinar, we present the design and performance testing of a single-use manufacturing-scale TFF system that can be operated in functionally or fully closed mode.

Webinar on regulatory expectations when implementing closed single use systems for final filtration and filling operations.
Single-Use Systems - A Prerequisite for Closed Processing in Final Filtration and Filling Operation Webinar

Learn about regulatory expectations when implementing single-use systems for final filtration and filling applications.

Webinar on updates to EU GMP Annex 1 and how this impacts sterilizing filtration in single use systems
How Updates to EU GMP Annex 1 Impact Sterilizing Filtration in Single-Use Systems Webinar

In this webinar, we discuss important elements of the revision to EU GMP Annex 1 and how single-use filtration systems can contribute to a holistic contamination control strategy.






BioContinuum™ Platform: Your enabler of the biomanufacturing facility of the future!

Advanced biomanufacturing technologies for upstream intensification
Upstream (USP) Process Intensification
  • Seed Train Intensification
  • Production & Harvest Intensification
Advanced biomanufacturing technologies for downstream intensification
Downstream (DSP) Process Intensification
  • Intensified Capture
  • Virus Inactivation
  • Flow Through Polishing
  • Single-Pass TFF
PAT for bioprocess monitoring and control of CPPs and CQAs
Process Analytical Technology (PAT)
  • Raman Spectroscopy
  • Automated Aseptic Sampling
Two scientists in the lab reviewing bioprocessing data visualizations on a computer monitor
Bioprocessing Data Analytics Software
  • Bio4C ProcessPad™ Software
Female scientist in lab coat using laptop using control software to automate, monitor, and control a bioprocess unit operation
Bioprocessing Automation and Control Software
  • Bio4C Orchestrator™ Software
  • Bio4C ACE™ Software

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