Merck
All Photos(3)

1.02735

SAFC

L-Cysteine hydrochloride monohydrate

EMPROVE® EXPERT, Ph. Eur., JP, USP

Synonym(s):
Cys, L-Cysteinium Chloride Monohydrate, L-Cysteine Hydrochloride, Monohydrate
Linear Formula:
HSCH2CH(NH2)COOH · HCl · H2O
CAS Number:
Molecular Weight:
175.63
Beilstein:
5158059
MDL number:
EC Index Number:
200-157-7

Quality Level

Agency

JP
Ph. Eur.
USP

vapor pressure

<0.1 hPa ( 20 °C)

product line

EMPROVE® EXPERT

assay

98.5-101.0% dry basis (alkalimetric)

form

crystalline powder

pH

0.8-1.2 (20 °C, 100 g/L in H2O)

mp

168-170 °C

solubility

650 g/L

density

1.54 g/cm3

bulk density

780 kg/m3

anion traces

sulfate (SO42-): ≤300 ppm

cation traces

Fe: ≤20 ppm
heavy metals (as Pb): ≤10 ppm

storage temp.

2-30°C

SMILES string

O.Cl.N[C@@H](CS)C(O)=O

InChI

1S/C3H7NO2S.ClH.H2O/c4-2(1-7)3(5)6;;/h2,7H,1,4H2,(H,5,6);1H;1H2/t2-;;/m0../s1

InChI key

QIJRTFXNRTXDIP-JIZZDEOASA-N

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Biochem/physiol Actions

NMDA glutamatergic receptor antagonist.

Analysis Note

Assay (alkalimetric, calculated on dried substance): 98.5 - 101.0 %
Identity (IR-spectrum): passes test
Identity (Chloride): passes test
Appearance: white to almost white crystalline powder or colorless crystals
Appearance of solution (25 g/l, water): clear and not more intense in color than reference solution BY₆
Spec. rotation (α 20/D, 80 g/l, hydrochloric acid 250 g/l, calc. on dried substance): +5.5 to +7.0
Spec. rotation (α 25/D, 80 g/l, hydrochloric acid 6 mol/l, calc. on dried substance): +5.7 to +6.8
Sulfate (SO₄): ≤ 300 ppm
Heavy metals (as Pb): ≤ 10 ppm
Fe (Iron): ≤ 20 ppm
Related Compounds, total (TLC): ≤ 0.5 %
Ninhydrin-positive substances (LC)(impurity A (570 nm)): ≤ 0.5 %
Ninhydrin-positive substances (LC)(any ninhydrin-positive impurity): ≤ 0.2 %
Ninhydrin-positive substances (LC) (ammonium (570 nm)): ≤ 0.02 %
Ninhydrin-positive substances (LC)(total impurities): ≤ 1.0 %
Residual solvents (ICH Q3C): excluded by manufacturing proces
Sulfated ash (600 °C): ≤ 0.1 %
Loss on drying (Vacuum < 0.7 kPa, P₂O₅, 24 h): 8.0 - 12.0 %
Bacterial endotoxins: ≤ 6.0 I.U./g
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph. Eur., USP.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Quality

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