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Merck

C0685000

Cefotaxime sodium

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Cefotaxime sodium salt, Cefotaxim sodium salt

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20 MG

€145.00

€145.00

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About This Item

Empirical Formula (Hill Notation):
C16H16N5NaO7S2
CAS Number:
64485-93-4
Molecular Weight:
477.45
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329774812
MDL number:
MFCD00079073
Beilstein/REAXYS Number:
5711411

Key Documents

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InChI

1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

SMILES string

[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O

InChI key

AZZMGZXNTDTSME-JUZDKLSSSA-M

grade

pharmaceutical primary standard

API family

cefotaxime

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

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This Item
C7912C7039PHR2099
Cefotaxime sodium European Pharmacopoeia (EP) Reference Standard

C0685000

Cefotaxime sodium

Cefotaxime sodium salt potency: 916-964 μg per mg

Sigma-Aldrich

C7912

Cefotaxime sodium salt

Cefotaxime sodium salt suitable for plant cell culture, BioReagent, powder or crystals

Sigma-Aldrich

C7039

Cefotaxime sodium salt

Cefotaxime Sodium Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2099

Cefotaxime Sodium

grade

pharmaceutical primary standard

grade

-

grade

-

grade

certified reference material, pharmaceutical secondary standard

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

agriculture

application(s)

pharmaceutical small molecule

format

neat

format

-

format

-

format

-

API family

cefotaxime

API family

-

API family

-

API family

cefotaxime

Application

Cefotaxime sodium EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Mode of Action: Inhibits bacterial cell wall synthesis.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Broad spectrum third generation cephalosporin antibiotic.
Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Yidan Cui et al.
PloS one, 7(11), e48880-e48880 (2012-11-16)
Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae poses serious challenges to clinicians because of its resistance to many classes of antibiotics. The mechanism of synergistic activity of a combination of (-)-epigallocatechin-3-gallate (EGCG) and β-lactam antibiotics cefotaxime was studied on Extended-spectrum β-lactamase producing Escherichia
I Mounchetrou Njoya et al.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 17(34) (2012-09-04)
In April 2012, a cluster of two cases of meningococcal disease caused by rifampicin-resistant C meningococci was reported in the Champagne-Ardenne region, France. The two cases occurred in a student population living in the same town but studying at different
Martijn F Schenk et al.
PLoS genetics, 8(6), e1002783-e1002783 (2012-07-05)
For a quantitative understanding of the process of adaptation, we need to understand its "raw material," that is, the frequency and fitness effects of beneficial mutations. At present, most empirical evidence suggests an exponential distribution of fitness effects of beneficial
Ryuichi Nakano et al.
Journal of medical microbiology, 61(Pt 12), 1727-1735 (2012-09-01)
Proteus mirabilis is a common cause of urinary tract infection. Wild-type P. mirabilis strains are usually susceptible to penicillins and cephalosporins, but occurrences of P. mirabilis producing extended-spectrum β-lactamases (ESBLs) have been recently reported. Here, we surveyed the prevalence of
Elena Ojer-Usoz et al.
Meat science, 93(2), 316-321 (2012-10-16)
Patterns of resistance in β-lactamase-producing Enterobacteriaceae family were investigated in isolates from 141 meat products (beef, poultry and pork) purchased in Spain. The strains that grow in ChromID ESBL agar plates were confirmed using the paired disk diffusion method. Resistance
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