Merck

Organic Building Blocks

Sample heterocyclic building blocks for organic synthesis

Although new catalysts and reagents are steadily discovered in synthetic chemistry, scientists continue to search for the most appropriate substrate for their research. It might be easy to overlook organic building blocks, but access to the right substrate is every bit as important as having the tools to transform it into the desired target. 

Organic building blocks are organic functionalized molecules: the basic components for organic synthesis. They are used for bottom-up modular assembly of molecular architectures, such as supra-molecular complexes, metal-organic frameworks, organic molecular constructs, and nanoparticles. Thereby, they play a fundamental role in medicinal chemistry, organic chemistry, and material chemistry.  

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We offer a diverse array of organic building blocks:

  • Alkanes
  • Alkenes
  • Alkynes
  • Allenes
  • Arenes
  • Arsenic Compounds
  • Baran Functionalized Building Blocks
  • Baran Hindered Amines
  • Building Blocks and Chiral Small Molecules from Liverpool ChiroChem
  • Building Blocks for SuFEx: The Next Click Reaction
  • Carbenium Salts
  • Carbonyl Compounds

Spark your chemical synthesis with our one-stop source of chemical reagents. Alkynes are critical substrates in Sonogashira coupling and click chemistry. Pyridines are extremely common building blocks for a wide range of synthetic targets. Aldehydes are perennially attractive building blocks due to their ability to easily react with a variety of nucleophiles. Hindered amines are classically very challenging to access with current synthetic methods with broad application in synthesis, drug discovery, and agriscience. By combining our core offering with a diverse suite of partners’ compounds, we have the industry’s most comprehensive selection of organic building blocks. 


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  • SuFEx: Sulfonyl Fluorides that Participate in the Next Click Reaction

    In collaboration with K. Barry Sharpless and coworkers, we offer a variety of sulfonyl fluoride reagents that undergo a “Click II” reaction.

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    This robust protocol for hydrosilylation of terminal acetylenes to give α-vinylsilanes using [Cp*Ru(MeCN)3]PF6, as well as a number of other catalysts for hydrosilylation, comes from the Trost group at Stanford University.

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    Catalytic asymmetric epoxidation of alkenes has been the focus of many research efforts over the past two decades, the best known methods probably being those developed by Sharpless and Jacobsen-Katsuki.




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