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Sulfonyl Chlorides and Sulfonamides
Sulfonyl chlorides are often chosen as building blocks in medicinal chemistry for their ability to easily react with heterocyclic amines to create complex sulfonamides.
The chiral auxiliaries TADDOLs (α,α,α,α-tetraaryl-1,3-dioxolane-4,5- dimethanols) developed by Seebach's group have found numerous applications in asymmetric synthesis ranging from utilization as stoichiometric chiral reagents or in Lewis acid mediated reactions, to roles in catalytic hydrogenation and stereoregular metathesis polymerization.
Trimethyl(trifluoromethyl)silane (Ruppert–Prakash Reagent)
Technical article for Trimethyl(trifluoromethyl)silane (Ruppert–Prakash Reagent)
PhenoFluor™ Deoxyfluorination Solution
PhenoFluor™ enables one-step conversion of phenols to aryl fluorides, facilitating fluorination without pre-activation.
Fluoroalkylation: Expansion of Togni Reagents
Fluoroalkylation toolbox expands with various reagents for late-stage fluoroalkylation in organic synthesis and medicinal chemistry.
Deoxyfluorination with 2-Pyridinesulfonyl Fluoride (PyFluor)
The prevalence of organofluorine compounds in industry and drug design necessitates the ability to introduce C–F bonds to molecules.
XtalFluor-E® and XtalFluor-M®: Convenient, Crystalline Deoxofluorination Reagents
This is an article regarding XtalFluor-E® and XtalFluor-M®: Convenient, Crystalline Deoxofluorination Reagents.
AlPhos and [(AlPhosPd)2•COD] for Pd-Catalyzed Fluorination
Fluorine containing aromatics (ArF) are desirable compounds with applications in medicinal chemistry and the agricultural industry.
Fluorinated Azides: Click Chemistry Meets Fluorine
Fluorinated azides are a new tool that can be used to introduce fluorinated groups to molecules. These molecules can utilize click chemistry to easily add fluorinated groups.
Trifluoromethylator™, A Robust Arene Trifluoromethylation Reagent: (Phen)Cu-CF3*
(Phen)Cu-CF3 (cat. #L510009) is an easily handled, thermally stable, single-component reagent for the trifluoromethylation of aryl iodides.
Recent Advances in the Catalytic Transformations
This article details the latest progress in synthesizing alkylsulfonyl fluorides through different approaches that utilize photoredox catalysis, electrocatalysis, transition-metal catalysis, and organocatalysis. The alkylsulfonyl fluorides thus prepared could be utilized further in sulfur(VI) fluoride exchange (SuFEx) click reactions.
Diethylaminosulfur Trifluoride (DAST)
Diethylaminosulfur trifluoride (DAST) facilitates nucleophilic fluorination in selective reactions with alcohols, ketones, and other compounds.
Selectfluor™ (F-TEDA) is a mild, stable reagent for electrophilic fluorination, enhancing user-friendly fluorination reactions.
AISF: A Solid Alternative to Sulfuryl Fluoride Gas
ASIF provides bench-stable alternative to sulfuryl fluoride gas for installing SO2F functional group in organic synthesis.
Acid Halogenation Reagents
Fluoroamidinium salts advance acid halogenation with greater stability and no oxazolones conversion compared to chlorides.