TRC Library Citations

The MISSION^® TRC1.5 human and mouse shRNA libraries are the proven performers for small-scale to high-throughput RNAi screening. Below you will find a selection of papers where researchers have published in peer-reviewed journals using the TRC1/1.5 library and have cited The Broad Institute or us as their source of high quality reagents. Unlike other shRNA libraries, the clones cited in these publications are the same clones available from us. If a specific clone is not found in our catalog, please inquire here for availability.

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How to Cite the TRC Library

In scientific publications, the human library should be referred to as MISSION^® TRC-Hs 1.0 (Human) while the mouse library should be referred to as MISSION^® TRC-Mm 1.0 (Mouse). If your TRC library was purchased after July 2011, the human library should be referred to as MISSION^® TRC-Hs 1.5 (Human) while the mouse library should be referred to as MISSION^® TRC-Mm 1.5 (Mouse). If you experimented with our TRC2 library, the human library should be referred to as MISSION^® TRC-Hs 2.0 (Human) while the mouse library should be referred to as MISSION^® TRC-Mm 2.0 (Mouse).Individual clones should be identified by their unique TRC number (e.g. MISSION^® TRC shRNA TRCN0000030720).

MISSION® shRNA Publications

1. Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, et al. 2011. Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma. Science. 331(6024):1571-1576. https://doi.org/10.1126/science.1195970

2. Sevlever D, Jiang P, Yen SC. 2008. Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of ?-Synuclein and Generation of Its Carboxy-Terminally Truncated Species?. Biochemistry. 47(36):9678-9687. https://doi.org/10.1021/bi800699v

3. Zhang Y, Linn D, Liu Z, Melamed J, Tavora F, Young CY, Burger AM, Hamburger AW. 2008. EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. Mol Cancer Ther. 7(10):3176-3186. https://doi.org/10.1158/1535-7163.mct-08-0526

4. Zhang X, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL, McMahon SB. 2008. The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression. Molecular Cell. 29(1):102-111. https://doi.org/10.1016/j.molcel.2007.12.015

5. Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, et al. 2008. Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. 135(2):367-375. https://doi.org/10.1242/dev.013540

6. Seok Yang W, Stockwell BR. 2008. Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol. 9(6):R92. https://doi.org/10.1186/gb-2008-9-6-r92

7. Yamashita M, Kuwahara M, Suzuki A, Hirahara K, Shinnaksu R, Hosokawa H, Hasegawa A, Motohashi S, Iwama A, Nakayama T. 2008. Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. 205(5):1109-1120. https://doi.org/10.1084/jem.20072000

8. Wimmer-Kleikamp SH, Nievergall E, Gegenbauer K, Adikari S, Mansour M, Yeadon T, Boyd AW, Patani NR, Lackmann M. 2008. Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells. 112(3):721-732. https://doi.org/10.1182/blood-2007-11-121681

9. Wierzbicki A, Gil M, Ciesielski M, Fenstermaker RA, Kaneko Y, Rokita H, Lau JT, Kozbor D. 2008. Immunization with a Mimotope of GD2 Ganglioside Induces CD8+T Cells That Recognize Cell Adhesion Molecules on Tumor Cells. J Immunol. 181(9):6644-6653. https://doi.org/10.4049/jimmunol.181.9.6644

10. Wei D, Kanai M, Jia Z, Le X, Xie K. 2008. Krüppel-like Factor 4 Induces p27Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells. Cancer Res. 68(12):4631-4639. https://doi.org/10.1158/0008-5472.can-07-5953

11. Vasilcanu R, Vasilcanu D, Rosengren L, Natalishvili N, Sehat B, Yin S, Girnita A, Axelson M, Girnita L, Larsson O. 2008. Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and ?-arrestin1. Oncogene. 27(11):1629-1638. https://doi.org/10.1038/sj.onc.1210797

12. Varghese B, Barriere H, Carbone CJ, Banerjee A, Swaminathan G, Plotnikov A, Xu P, Peng J, Goffin V, Lukacs GL, et al. 2008. Polyubiquitination of Prolactin Receptor Stimulates Its Internalization, Postinternalization Sorting, and Degradation via the Lysosomal Pathway. MCB. 28(17):5275-5287. https://doi.org/10.1128/mcb.00350-08

13. Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I. 2008. Up-regulation of c-FLIPshort by NFAT contributes to apoptosis resistance of short-term activated T cells. 112(3):690-698. https://doi.org/10.1182/blood-2008-02-141382

14. Tsai RK, Discher DE. 2008. Inhibition of ?self? engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. 180(5):989-1003. https://doi.org/10.1083/jcb.200708043

15. Sun Y, Fang Y, Yoon M, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J. 2008. Phospholipase D1 is an effector of Rheb in the mTOR pathway. Proceedings of the National Academy of Sciences. 105(24):8286-8291. https://doi.org/10.1073/pnas.0712268105

16. Snider JL, Allison C, Bellaire BH, Ferrero RL, Cardelli JA. 2008. The ?1 Integrin Activates JNK Independent of CagA, and JNK Activation Is Required for Helicobacter pylori CagA+-induced Motility of Gastric Cancer Cells. Journal of Biological Chemistry. 283(20):13952-13963. https://doi.org/10.1074/jbc.m800289200

17. Sierra JR, Corso S, Caione L, Cepero V, Conrotto P, Cignetti A, Piacibello W, Kumanogoh A, Kikutani H, Comoglio PM, et al. 2008. Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages. 205(7):1673-1685. https://doi.org/10.1084/jem.20072602

18. Shimamura T, Li D, Ji H, Haringsma HJ, Liniker E, Borgman CL, Lowell AM, Minami Y, McNamara K, Perera SA, et al. 2008. Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance. Cancer Res. 68(14):5827-5838. https://doi.org/10.1158/0008-5472.can-07-5428

19. Sher F, Rößler R, Brouwer N, Balasubramaniyan V, Boddeke E, Copray S. 2008. Differentiation of Neural Stem Cells into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2. Stem Cells. 26(11):2875-2883. https://doi.org/10.1634/stemcells.2008-0121

20. Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, et al. 2008. The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes & Development. 22(19):2664-2676. https://doi.org/10.1101/gad.1703008

21. Shaikh FM, Seales EC, Clem WC, Hennessy KM, Zhuo Y, Bellis SL. 2008. Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms. Experimental Cell Research. 314(16):2941-2950. https://doi.org/10.1016/j.yexcr.2008.07.021

22. Sen N, Hara MR, Kornberg MD, Cascio MB, Bae B, Shahani N, Thomas B, Dawson TM, Dawson VL, Snyder SH, et al. 2008. Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol. 10(7):866-873. https://doi.org/10.1038/ncb1747

23. Roukens MG, Alloul-Ramdhani M, Moghadasi S, Op den Brouw M, Baker DA. 2008. Downregulation of Vertebrate Tel (ETV6) and Drosophila Yan Is Facilitated by an Evolutionarily Conserved Mechanism of F-Box-Mediated Ubiquitination. MCB. 28(13):4394-4406. https://doi.org/10.1128/mcb.01914-07

24. Rouget R, Auclair Y, Loignon M, Affar EB, Drobetsky EA. 2008. A Sensitive Flow Cytometry-based Nucleotide Excision Repair Assay Unexpectedly Reveals That Mitogen-activated Protein Kinase Signaling Does Not Regulate the Removal of UV-induced DNA Damage in Human Cells. Journal of Biological Chemistry. 283(9):5533-5541. https://doi.org/10.1074/jbc.m706257200

25. Pfister S, Janzarik WG, Remke M, Ernst A, Werft W, Becker N, Toedt G, Wittmann A, Kratz C, Olbrich H, et al. 2008. BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. J. Clin. Invest.. 118(5):1739-1749. https://doi.org/10.1172/jci33656

26. Park JT, Shih I, Wang T. 2008. Identification of Pbx1, a Potential Oncogene, as a Notch3 Target Gene in Ovarian Cancer. Cancer Res. 68(21):8852-8860. https://doi.org/10.1158/0008-5472.can-08-0517

27. Park Y, Yoon SK, Yoon J. 2008. TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. Biochemical and Biophysical Research Communications. 374(2):294-298. https://doi.org/10.1016/j.bbrc.2008.07.019

28. Nogueira E, Fidalgo M, Molnar A, Kyriakis J, Force T, Zalvide J, Pombo CM. 2008. SOK1 Translocates from the Golgi to the Nucleus upon Chemical Anoxia and Induces Apoptotic Cell Death. Journal of Biological Chemistry. 283(23):16248-16258. https://doi.org/10.1074/jbc.m709724200

29. Mortensen OV, Larsen MB, Prasad BM, Amara SG. 2008. Genetic Complementation Screen Identifies a Mitogen-activated Protein Kinase Phosphatase, MKP3, as a Regulator of Dopamine Transporter Trafficking. MBoC. 19(7):2818-2829. https://doi.org/10.1091/mbc.e07-09-0980

30. Martin-Granados C, Philp A, Oxenham SK, Prescott AR, Cohen PT. 2008. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. The International Journal of Biochemistry & Cell Biology. 40(10):2315-2332. https://doi.org/10.1016/j.biocel.2008.03.021

31. Magenta A, Fasanaro P, Romani S, Di Stefano V, Capogrossi MC, Martelli F. 2008. Protein Phosphatase 2A Subunit PR70 Interacts with pRb and Mediates Its Dephosphorylation. MCB. 28(2):873-882. https://doi.org/10.1128/mcb.00480-07

32. Lukashchuk V, McFarlane S, Everett RD, Preston CM. 2008. Human Cytomegalovirus Protein pp71 Displaces the Chromatin-Associated Factor ATRX from Nuclear Domain 10 at Early Stages of Infection. JVI. 82(24):12543-12554. https://doi.org/10.1128/jvi.01215-08

33. Loo Y, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez-Sobrido L, Akira S, Gill MA, Garci?a-Sastre A, Katze MG, et al. 2008. Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity. JVI. 82(1):335-345. https://doi.org/10.1128/jvi.01080-07

34. Liau S, Whang E. 2008. HMGA1 Is a Molecular Determinant of Chemoresistance to Gemcitabine in Pancreatic Adenocarcinoma. Clin Cancer Res. 14(5):1470-1477. https://doi.org/10.1158/1078-0432.ccr-07-1450

35. Lepagnol-Bestel A, Maussion G, Boda B, Cardona A, Iwayama Y, Delezoide A, Moalic J, Muller D, Dean B, Yoshikawa T, et al. 2008. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. Mol Psychiatry. 13(4):385-397. https://doi.org/10.1038/sj.mp.4002120

36. Lamar JM, Pumiglia KM, DiPersio CM. 2008. An Immortalization-Dependent Switch in Integrin Function Up-regulates MMP-9 to Enhance Tumor Cell Invasion. Cancer Res. 68(18):7371-7379. https://doi.org/10.1158/0008-5472.can-08-1080

37. Koh SM, Chandrasekara K, Abbondandolo CJ, Coll TJ, Rutzen AR. 2008. VIP and VIP Gene Silencing Modulation of Differentiation Marker N-Cadherin and Cell Shape of Corneal Endothelium in Human Corneas Ex Vivo. Invest. Ophthalmol. Vis. Sci.. 49(8):3491. https://doi.org/10.1167/iovs.07-1543

38. Kim J, Kim JE, Liu H, Cao W, Chen J. 2008. Regulation of Interleukin-6-induced Hepatic Insulin Resistance by Mammalian Target of Rapamycin through the STAT3-SOCS3 Pathway. Journal of Biological Chemistry. 283(2):708-715. https://doi.org/10.1074/jbc.m708568200

39. Kappes F, Fahrer J, Khodadoust MS, Tabbert A, Strasser C, Mor-Vaknin N, Moreno-Villanueva M, Bu?rkle A, Markovitz DM, Ferrando-May E. 2008. DEK Is a Poly(ADP-Ribose) Acceptor in Apoptosis and Mediates Resistance to Genotoxic Stress. MCB. 28(10):3245-3257. https://doi.org/10.1128/mcb.01921-07

40. Jong A, Wu C, Prasadarao NV, Kwon-Chung KJ, Chang YC, Ouyang Y, Shackleford GM, Huang S. 2008. Invasion ofCryptococcus neoformansinto human brain microvascular endothelial cells requires protein kinase C-? activation. 10(9):1854-1865. https://doi.org/10.1111/j.1462-5822.2008.01172.x

41. Jiang CC, Lucas K, Avery-Kiejda KA, Wade M, deBock CE, Thorne RF, Allen J, Hersey P, Zhang XD. 2008. Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress. Cancer Res. 68(16):6708-6717. https://doi.org/10.1158/0008-5472.can-08-0349

42. Jiang CC, Lucas K, Avery-Kiejda KA, Wade M, deBock CE, Thorne RF, Allen J, Hersey P, Zhang XD. 2008. Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress. Cancer Res. 68(16):6708-6717. https://doi.org/10.1158/0008-5472.can-08-0349

43. Ji Z, Mei FC, Miller AL, Thompson E, Cheng X. 2008. Protein Kinase A (PKA) Isoform RII? Mediates the Synergistic Killing Effect of cAMP and Glucocorticoid in Acute Lymphoblastic Leukemia Cells. Journal of Biological Chemistry. 283(32):21920-21925. https://doi.org/10.1074/jbc.m803193200

44. Ji W, Yang L, Yu L, Yuan J, Hu D, Zhang W, Yang J, Pang Y, Li W, Lu J, et al. 2008. Epigenetic silencing of O6 -methylguanine DNA methyltransferase gene in NiS-transformed cells. 29(6):1267-1275. https://doi.org/10.1093/carcin/bgn012

45. Janoueix-Lerosey I, Lequin D, Brugières L, Ribeiro A, de Pontual L, Combaret V, Raynal V, Puisieux A, Schleiermacher G, Pierron G, et al. 2008. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature. 455(7215):967-970. https://doi.org/10.1038/nature07398

46. Ishikawa H, Barber GN. 2008. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature. 455(7213):674-678. https://doi.org/10.1038/nature07317

47. Hoskins EE, Gunawardena RW, Habash KB, Wise-Draper TM, Jansen M, Knudsen ES, Wells SI. 2008. Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway. Oncogene. 27(35):4798-4808. https://doi.org/10.1038/onc.2008.121

48. Hähnel PS, Thaler S, Antunes E, Huber C, Theobald M, Schuler M. 2008. Targeting AKT Signaling Sensitizes Cancer to Cellular Immunotherapy. Cancer Res. 68(10):3899-3906. https://doi.org/10.1158/0008-5472.can-07-6286

49. Gu J, Lim SO, Park YM, Jung G. 2008. A novel splice variant of occludin deleted in exon?9 and its role in cell apoptosis and invasion. 275(12):3145-3156. https://doi.org/10.1111/j.1742-4658.2008.06467.x

50. Goncalves S, Paupe V, Dassa EP, Rustin P. 2008. Deferiprone targets aconitase: Implication for Friedreich's ataxia treatment. BMC Neurol. 8(1): https://doi.org/10.1186/1471-2377-8-20

51. Gendron TF, McCartney S, Causevic E, Ko L, Yen S. 2008. Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau. Neuroscience Letters. 443(2):67-71. https://doi.org/10.1016/j.neulet.2008.07.052

52. Fung C, Lock R, Gao S, Salas E, Debnath J. 2008. Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival. MBoC. 19(3):797-806. https://doi.org/10.1091/mbc.e07-10-1092

53. Fukazawa T, Matsuoka J, Naomoto Y, Maeda Y, Durbin ML, Tanaka N. 2008. Malignant Pleural Mesothelioma?Targeted CREBBP/EP300 Inhibitory Protein 1 Promoter System for Gene Therapy and Virotherapy. Cancer Res. 68(17):7120-7129. https://doi.org/10.1158/0008-5472.can-08-0047

54. Frederick LA, Matthews JA, Jamieson L, Justilien V, Thompson EA, Radisky DC, Fields AP. 2008. Matrix metalloproteinase-10 is a critical effector of protein kinase C?-Par6?-mediated lung cancer. Oncogene. 27(35):4841-4853. https://doi.org/10.1038/onc.2008.119

55. Fattah FJ, Lichter NF, Fattah KR, Oh S, Hendrickson EA. 2008. Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells. Proceedings of the National Academy of Sciences. 105(25):8703-8708. https://doi.org/10.1073/pnas.0712060105

56. Escriva? M, Peiro? S, Herranz N, Villagrasa P, Dave N, Montserrat-Senti?s B, Murray SA, Franci? C, Gridley T, Virtanen I, et al. 2008. Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis. MCB. 28(5):1528-1540. https://doi.org/10.1128/mcb.02061-07

57. Eguchi J, Yan Q, Schones DE, Kamal M, Hsu C, Zhang MQ, Crawford GE, Rosen ED. 2008. Interferon Regulatory Factors Are Transcriptional Regulators of Adipogenesis. Cell Metabolism. 7(1):86-94. https://doi.org/10.1016/j.cmet.2007.11.002

58. Duan Z, Weinstein EJ, Ji D, Ames RY, Choy E, Mankin H, Hornicek FJ. 2008. Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer. Mol Cancer Ther. 7(8):2377-2385. https://doi.org/10.1158/1535-7163.mct-08-0316

59. Clarke E, Rahman N, Page N, Rolph MS, Stewart GJ, Jones GJ. 2008. Functional characterization of the atopy-associated gene PHF11. Journal of Allergy and Clinical Immunology. 121(5):1148-1154.e3. https://doi.org/10.1016/j.jaci.2008.02.028

60. Cheng GZ, Zhang W, Sun M, Wang Q, Coppola D, Mansour M, Xu L, Costanzo C, Cheng JQ, Wang L. 2008. Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function. Journal of Biological Chemistry. 283(21):14665-14673. https://doi.org/10.1074/jbc.m707429200

61. Chang T, Yu D, Lee Y, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT. 2008. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet. 40(1):43-50. https://doi.org/10.1038/ng.2007.30

62. Caramel J, Medjkane S, Quignon F, Delattre O. 2008. The requirement for SNF5/INI1 in adipocyte differentiation highlights new features of malignant rhabdoid tumors. Oncogene. 27(14):2035-2044. https://doi.org/10.1038/sj.onc.1210847

63. Caramel J, Quignon F, Delattre O. 2008. RhoA-Dependent Regulation of Cell Migration by the Tumor Suppressor hSNF5/INI1. Cancer Res. 68(15):6154-6161. https://doi.org/10.1158/0008-5472.can-08-0115

64. Callejas-Valera JL, Guinea-Viniegra J, Ramírez-Castillejo C, Recio JA, Galan-Moya E, Martinez N, Rojas JM, Cajal SRy, Sánchez-Prieto R. 2008. E1a Gene Expression Blocks the ERK1/2 Signaling Pathway by Promoting Nuclear Localization and MKP Up-regulation. Journal of Biological Chemistry. 283(19):13450-13458. https://doi.org/10.1074/jbc.m709230200

65. Borrelli S, Candi E, Alotto D, Castagnoli C, Melino G, Viganò MA, Mantovani R. 2009. p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis. Cell Death Differ. 16(2):253-263. https://doi.org/10.1038/cdd.2008.147

66. Bernard-Pierrot I, Gruel N, Stransky N, Vincent-Salomon A, Reyal F, Raynal V, Vallot C, Pierron G, Radvanyi F, Delattre O. 2008. Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer. Cancer Res. 68(17):7165-7175. https://doi.org/10.1158/0008-5472.can-08-1360

67. Bao S, Wu Q, Li Z, Sathornsumetee S, Wang H, McLendon RE, Hjelmeland AB, Rich JN. 2008. Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth. Cancer Res. 68(15):6043-6048. https://doi.org/10.1158/0008-5472.can-08-1079

68. Azran-Shaish I, Tabakin-Fix Y, Huleihel M, Bakhanashvili M, Aboud M. 2008. HTLV-1 Tax-induced NF-?B activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity. J Mol Med. 86(7):799-814. https://doi.org/10.1007/s00109-008-0335-1

69. Al-Hakim A, Zagorska A, Chapman L, Deak M, Peggie M, Alessi D. 2008. Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains. 411(2):249-260. https://doi.org/10.1042/bj20080067

70. Ahmed AU, Schmidt RL, Park CH, Reed NR, Hesse SE, Thomas CF, Molina JR, Deschamps C, Yang P, Aubry MC, et al. 2008. Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth. 100(22):1606-1629. https://doi.org/10.1093/jnci/djn365

71. Yang L, Sun M, Sun X, Cheng GZ, Nicosia SV, Cheng JQ. 2007. Akt Attenuation of the Serine Protease Activity of HtrA2/Omi through Phosphorylation of Serine 212. Journal of Biological Chemistry. 282(15):10981-10987. https://doi.org/10.1074/jbc.m700445200

72. Villa-Moruzzi E. 2007. Targeting of FAK Ser910 by ERK5 and PP1? in non-stimulated and phorbol ester-stimulated cells. 408(1):7-18. https://doi.org/10.1042/bj20070058

73. Haar EV, Lee S, Bandhakavi S, Griffin TJ, Kim D. 2007. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol. 9(3):316-323. https://doi.org/10.1038/ncb1547

74. Scholl C, Bansal D, Döhner K, Eiwen K, Huntly BJ, Lee BH, Rücker FG, Schlenk RF, Bullinger L, Döhner H, et al. 2007. The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J. Clin. Invest.. 117(4):1037-1048. https://doi.org/10.1172/jci30182

75. Schmidt RL, Park CH, Ahmed AU, Gundelach JH, Reed NR, Cheng S, Knudsen BE, Tang AH. 2007. Inhibition of RAS-Mediated Transformation and Tumorigenesis by Targeting the Downstream E3 Ubiquitin Ligase Seven in Absentia Homologue. Cancer Research. 67(24):11798-11810. https://doi.org/10.1158/0008-5472.can-06-4471

76. Sánchez-Sánchez F, Martínez-Redondo F, Aroca-Aguilar JD, Coca-Prados M, Escribano J. 2007. Characterization of the Intracellular Proteolytic Cleavage of Myocilin and Identification of Calpain II as a Myocilin-processing Protease. Journal of Biological Chemistry. 282(38):27810-27824. https://doi.org/10.1074/jbc.m609608200

77. Rizzi M, Tschan MP, Britschgi C, Britschgi A, Hügli B, Grob TJ, Leupin N, Mueller BU, Simon H, Ziemiecki A, et al. 2007. The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. Journal of Leukocyte Biology. 81(6):1599-1608. https://doi.org/10.1189/jlb.0606400

78. Ravitz MJ, Chen L, Lynch M, Schmidt EV. 2007. c-myc Repression of TSC2 Contributes to Control of Translation Initiation and Myc-Induced Transformation. Cancer Res. 67(23):11209-11217. https://doi.org/10.1158/0008-5472.can-06-4351

79. Qian Y, Schmidt RJ, Zhang Y, Chu S, Lin A, Wang H, Wang X, Beyer TP, Bensch WR, Li W, et al. 2007. Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. Journal of Lipid Research. 48(7):1488-1498. https://doi.org/10.1194/jlr.m700071-jlr200

80. Pottier N, Cheok MH, Yang W, Assem M, Tracey L, Obenauer JC, Panetta JC, Relling MV, Evans WE. Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter snp that alters PARP1 binding and SMARCB1 expression. Human Molecular Genetics. 16(19):2261-2271. https://doi.org/10.1093/hmg/ddm178

81. Patel JH, McMahon SB. 2007. BCL2 Is a Downstream Effector of MIZ-1 Essential for Blocking c-MYC-induced Apoptosis. Journal of Biological Chemistry. 282(1):5-13. https://doi.org/10.1074/jbc.m609138200

82. Pallerla SR, Pan Y, Zhang X, Esko JD, Grobe K. 2007. Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development. Dev. Dyn.. 236(2):556-563. https://doi.org/10.1002/dvdy.21038

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88. Kanematsu A, Ramachandran A, Adam RM. 2007. GATA-6 mediates human bladder smooth muscle differentiation: involvement of a novel enhancer element in regulating ?-smooth muscle actin gene expression. American Journal of Physiology-Cell Physiology. 293(3):C1093-C1102. https://doi.org/10.1152/ajpcell.00225.2007

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94. Fang H, Strom SC, Ellis E, Duanmu Z, Fu J, Duniec-Dmuchowski Z, Falany CN, Falany JL, Kocarek TA, Runge-Morris M. 2007. Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4? and Pregnane X Receptor. J Pharmacol Exp Ther. 323(2):586-598. https://doi.org/10.1124/jpet.107.124610

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BROAD PUBLICATIONS

1. Ali N, Karlsson C, Aspling M, Hu G, Hacohen N, Scadden DT, Larsson J. 2009. Forward RNAi screens in primary human hematopoietic stem/progenitor cells. 113(16):3690-3695. https://doi.org/10.1182/blood-2008-10-176396

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3. Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, et al. 2008. CDK8 is a colorectal cancer oncogene that regulates ?-catenin activity. Nature. 455(7212):547-551. https://doi.org/10.1038/nature07179

4. Fröhling S, Scholl C, Levine RL, Loriaux M, Boggon TJ, Bernard OA, Berger R, Döhner H, Döhner K, Ebert BL, et al. 2007. Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles. Cancer Cell. 12(6):501-513. https://doi.org/10.1016/j.ccr.2007.11.005

5. Jones DC. 2006. Regulation of Adult Bone Mass by the Zinc Finger Adapter Protein Schnurri-3. Science. 312(5777):1223-1227. https://doi.org/10.1126/science.1126313

6. Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A. 2008. Regulation of CD45 Alternative Splicing by Heterogeneous Ribonucleoprotein, hnRNPLL. Science. 321(5889):686-691. https://doi.org/10.1126/science.1157610

7. Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong S, Walford GA, Sugiana C, Boneh A, Chen WK, et al. 2008. A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology. Cell. 134(1):112-123. https://doi.org/10.1016/j.cell.2008.06.016

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9. Seok Yang W, Stockwell BR. 2008. Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol. 9(6):R92. https://doi.org/10.1186/gb-2008-9-6-r92

10. Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, et al. 2007. Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene. Cell. 129(6):1065-1079. https://doi.org/10.1016/j.cell.2007.03.052

11. Fotiadou PP, Takahashi C, Rajabi HN, Ewen ME. 2007. Wild-Type NRas and KRas Perform Distinct Functions during Transformation. MCB. 27(19):6742-6755. https://doi.org/10.1128/mcb.00234-07

12. Kim M, Gans JD, Nogueira C, Wang A, Paik J, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, et al. 2006. Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene. Cell. 125(7):1269-1281. https://doi.org/10.1016/j.cell.2006.06.008

13. Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, et al. 2006. A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen. Cell. 124(6):1283-1298. https://doi.org/10.1016/j.cell.2006.01.040

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