DHFR
dihydrofolate reductase
Synonyms:
DHFRP1, DYR
Species:
Human DHFR (1719), Mouse Dhfr (13361), Rat Dhfr (24312), fruit fly Dhfr (42003), Zebrafish dhfr (81882), domestic guinea pig Dhfr (100729225), naked mole-rat Dhfr (101701790), domestic cat DHFR (101087964), cow DHFR (508809), dog DHFR (609048) ...More
UniProtKB ID:
Gene ID:
- Human(1719) Summary: Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. [provided by RefSeq, Jul 2008]
- Mouse(13361) dihydrofolate reductase
- Rat(24312) dihydrofolate reductase
- fruit fly(42003) Dihydrofolate reductase
- Zebrafish(81882) dihydrofolate reductase
- domestic guinea pig(100729225) dihydrofolate reductase
- naked mole-rat(101701790) dihydrofolate reductase
- domestic cat(101087964) dihydrofolate reductase
- cow(508809) dihydrofolate reductase
- dog(609048) dihydrofolate reductase
- chicken(427317) dihydrofolate reductase
- Domestic Rabbit(100359209) dihydrofolate reductase
- sheep(101121421) dihydrofolate reductase
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Activity Assay
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-DHFR antibody produced in mouse, clone 2B10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-DHFR, N-terminal antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Methotrexate for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Methotrexate for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Kits
Product Number
Description
Species
Proteins
esiRNA
Product Number
Description
Species