DUSP11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
Synonyms:
PIR1
Species:
Human DUSP11 (8446), Mouse Dusp11 (72102), Rat Dusp11 (297412), sheep DUSP11 (101113742), chicken DUSP11 (423818), domestic cat DUSP11 (101098861), cow DUSP11 (508944), dog DUSP11 (483110), Zebrafish dusp11 (550417), domestic guinea pig Dusp11 (100713554)
UniProtKB ID:
Gene ID:
- Human(8446) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
- Mouse(72102) dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
- Rat(297412) dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
- sheep(101113742) dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
- chicken(423818) dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
- domestic cat(101098861) dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
- cow(508944) dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
- dog(483110) dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
- Zebrafish(550417) dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
- domestic guinea pig(100713554) dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
- naked mole-rat(101713434) dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
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