MANEA
mannosidase, endo-alpha
Synonyms:
ENDO, hEndo
Species:
Human MANEA (79694), Mouse Manea (242362), Rat Manea (140808), domestic guinea pig Manea (100718937), dog MANEA (481925), chicken MANEA (421807), Zebrafish manea (447827), sheep MANEA (101106778), cow MANEA (512853), Horse MANEA (100065922) ...More
UniProtKB ID:
Gene ID:
- Human(79694) Summary: N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]
- Mouse(242362) mannosidase, endo-alpha
- Rat(140808) mannosidase, endo-alpha
- domestic guinea pig(100718937) mannosidase, endo-alpha
- dog(481925) mannosidase, endo-alpha
- chicken(421807) mannosidase, endo-alpha
- Zebrafish(447827) mannosidase, endo-alpha
- sheep(101106778) mannosidase, endo-alpha
- cow(512853) mannosidase, endo-alpha
- Horse(100065922) mannosidase, endo-alpha
- domestic cat(101101567) mannosidase, endo-alpha
- naked mole-rat(101724745) mannosidase, endo-alpha
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