MARCH2
membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
Synonyms:
MARCH-II, RNF172
Species:
Human MARCH2 (51257), Mouse March2 (224703), Rat March2 (362849), Zebrafish march2 (555611), domestic guinea pig March2 (100733733), domestic cat MARCH2 (101090087), cow MARCH2 (508949), dog MARCH2 (611624), naked mole-rat March2 (101720054), sheep MARCH2 (101103806)
UniProtKB ID:
Gene ID:
- Human(51257) Summary: MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]
- Mouse(224703) membrane-associated ring finger (C3HC4) 2
- Rat(362849) membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
- Zebrafish(555611) membrane-associated ring finger (C3HC4) 2
- domestic guinea pig(100733733) membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
- domestic cat(101090087) membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
- cow(508949) membrane-associated ring finger (C3HC4) 2
- dog(611624) membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
- naked mole-rat(101720054) membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
- sheep(101103806) membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
- chicken(420062) membrane-associated ring finger (C3HC4) 2
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