MLH3
mutL homolog 3
Synonyms:
HNPCC7
Species:
Human MLH3 (27030), Mouse Mlh3 (217716), Rat Mlh3 (314320), Domestic Rabbit MLH3 (100339094), sheep MLH3 (101109183), dog MLH3 (480389), domestic guinea pig Mlh3 (100735009), domestic cat MLH3 (101096575), Thale Cress MLH3 (829704), Zebrafish mlh3 (568323) ...More
UniProtKB ID:
Gene ID:
- Human(27030) Summary: This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
- Mouse(217716) mutL homolog 3 (E coli)
- Rat(314320) mutL homolog 3 (E. coli)
- Domestic Rabbit(100339094) mutL homolog 3 (E. coli)
- sheep(101109183) mutL homolog 3 (E. coli)
- dog(480389) mutL homolog 3 (E. coli)
- domestic guinea pig(100735009) mutL homolog 3 (E. coli)
- domestic cat(101096575) mutL homolog 3 (E. coli)
- Thale Cress(829704) DNA mismatch repair protein MLH3
- Zebrafish(568323) mutL homolog 3 (E. coli)
- Horse(100057292) mutL homolog 3 (E. coli)
- chicken(100859200) mutL homolog 3 (E. coli)
- naked mole-rat(101723287) mutL homolog 3 (E. coli)
- cow(786279) mutL homolog 3 (E. coli)
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