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Merck

MTHFS

5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)

Synonyms:
HsT19268
Species:
Human MTHFS (10588), Mouse Mthfs (107885), Rat Mthfs (300886), cow MTHFS (513372), sheep MTHFS (101114310), domestic guinea pig Mthfs (101787293), naked mole-rat Mthfs (101702108), chicken MTHFS (415484), domestic cat MTHFS (101093689), dog MTHFS (610157)
UniProtKB ID:
P49914, H3BQ75
Gene ID:
  • Human(10588) Summary: The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
  • Mouse(107885) 5, 10-methenyltetrahydrofolate synthetase
  • Rat(300886) 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
  • cow(513372) 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
  • sheep(101114310) 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
  • domestic guinea pig(101787293) 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
  • naked mole-rat(101702108) 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
  • chicken(415484) 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
  • domestic cat(101093689) 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
  • dog(610157) 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)

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