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Merck

PICALM

phosphatidylinositol binding clathrin assembly protein

Synonyms:
CALM, CLTH, LAP
Species:
Human PICALM (8301), Mouse Picalm (233489), Rat Picalm (89816), naked mole-rat Picalm (101706016), sheep PICALM (101103193), chicken PICALM (425991), domestic cat PICALM (101094948), Horse PICALM (100050701), cow PICALM (513579), domestic guinea pig Picalm (100729067)
UniProtKB ID:
Q13492, B4DTM3, E9PN05, F8VPG7, O60700, Q4LE54, Q6GMQ6, Q86XZ9
Gene ID:
  • Human(8301) Summary: This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
  • Mouse(233489) phosphatidylinositol binding clathrin assembly protein
  • Rat(89816) phosphatidylinositol binding clathrin assembly protein
  • naked mole-rat(101706016) phosphatidylinositol binding clathrin assembly protein
  • sheep(101103193) phosphatidylinositol binding clathrin assembly protein
  • chicken(425991) phosphatidylinositol binding clathrin assembly protein
  • domestic cat(101094948) phosphatidylinositol binding clathrin assembly protein
  • Horse(100050701) phosphatidylinositol binding clathrin assembly protein
  • cow(513579) phosphatidylinositol binding clathrin assembly protein
  • domestic guinea pig(100729067) phosphatidylinositol binding clathrin assembly protein
  • dog(476780) phosphatidylinositol binding clathrin assembly protein

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