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Merck

PIGA

phosphatidylinositol glycan anchor biosynthesis, class A

Synonyms:
GPI3, MCAHS2, PIG-A
Species:
Human PIGA (5277), Mouse Piga (18700), Rat Piga (363464), domestic guinea pig Piga (100713611), naked mole-rat Piga (101724876), cow PIGA (100139601), sheep PIGA (101102455), dog PIGA (491748), domestic cat PIGA (101094735), Horse PIGA (100055827) ...More
UniProtKB ID:
P37287, B4E0V2, Q16025, Q16250
Gene ID:
  • Human(5277) Summary: This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]
  • Mouse(18700) phosphatidylinositol glycan anchor biosynthesis, class A
  • Rat(363464) phosphatidylinositol glycan anchor biosynthesis, class A
  • domestic guinea pig(100713611) phosphatidylinositol glycan anchor biosynthesis, class A
  • naked mole-rat(101724876) phosphatidylinositol glycan anchor biosynthesis, class A
  • cow(100139601) phosphatidylinositol glycan anchor biosynthesis, class A
  • sheep(101102455) phosphatidylinositol glycan anchor biosynthesis, class A
  • dog(491748) phosphatidylinositol glycan anchor biosynthesis, class A
  • domestic cat(101094735) phosphatidylinositol glycan anchor biosynthesis, class A
  • Horse(100055827) phosphatidylinositol glycan anchor biosynthesis, class A
  • Zebrafish(791759) phosphatidylinositol glycan anchor biosynthesis, class A
  • chicken(418624) phosphatidylinositol glycan anchor biosynthesis, class A

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