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Merck

TMC8

transmembrane channel-like 8

Synonyms:
EV2, EVER2, EVIN2
Species:
Human TMC8 (147138), Mouse Tmc8 (217356), Rat Tmc8 (688276), domestic guinea pig Tmc8 (100724540), naked mole-rat Tmc8 (101698806), dog TMC8 (483342), cow TMC8 (513813), sheep TMC8 (101114540), domestic cat TMC8 (101080594)
UniProtKB ID:
Q8IU68, Q2YDC0, Q8IWU7, Q8N358, Q8NF04
Gene ID:
  • Human(147138) Summary: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
  • Mouse(217356) transmembrane channel-like gene family 8
  • Rat(688276) transmembrane channel-like 8
  • domestic guinea pig(100724540) transmembrane channel-like 8
  • naked mole-rat(101698806) transmembrane channel-like 8
  • dog(483342) transmembrane channel-like 8
  • cow(513813) transmembrane channel-like 8
  • sheep(101114540) transmembrane channel-like 8
  • domestic cat(101080594) transmembrane channel-like 8

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