TRAF1
TNF receptor-associated factor 1
Synonyms:
EBI6, MGC:10353
Species:
Human TRAF1 (7185), Mouse Traf1 (22029), Rat Traf1 (687813), cow TRAF1 (540944), dog TRAF1 (612709), chicken TRAF1 (417123), Zebrafish traf1 (100148503), naked mole-rat Traf1 (101710804), domestic guinea pig Traf1 (100723139), sheep TRAF1 (101122077) ...More
UniProtKB ID:
Gene ID:
- Human(7185) Summary: The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Mouse(22029) TNF receptor-associated factor 1
- Rat(687813) TNF receptor-associated factor 1
- cow(540944) TNF receptor-associated factor 1
- dog(612709) TNF receptor-associated factor 1
- chicken(417123) TNF receptor-associated factor 1
- Zebrafish(100148503) TNF receptor-associated factor 1
- naked mole-rat(101710804) TNF receptor-associated factor 1
- domestic guinea pig(100723139) TNF receptor-associated factor 1
- sheep(101122077) TNF receptor-associated factor 1
- Domestic Rabbit(100338847) TNF receptor-associated factor 1
- domestic cat(101087620) TNF receptor-associated factor 1
- Horse(100067681) TNF receptor-associated factor 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TRAF1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, mouse, rabbit
Application
western blot