ZP2
zona pellucida glycoprotein 2 (sperm receptor)
Synonyms:
ZPA, Zp-2
Species:
Human ZP2 (7783), Mouse Zp2 (22787), Rat Zp2 (81828), cow ZP2 (280963), domestic cat ZP2 (493977), dog ZP2 (403988), domestic guinea pig Zp2 (100713508), naked mole-rat Zp2 (101706160), Domestic Rabbit ZP2 (100009069), sheep ZP2 (101123598)
UniProtKB ID:
Gene ID:
- Human(7783) Summary: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. [provided by RefSeq, Jul 2008]
- Mouse(22787) zona pellucida glycoprotein 2
- Rat(81828) zona pellucida glycoprotein 2 (sperm receptor)
- cow(280963) zona pellucida glycoprotein 2 (sperm receptor)
- domestic cat(493977) zona pellucida glycoprotein 2 (sperm receptor)
- dog(403988) zona pellucida glycoprotein 2 (sperm receptor)
- domestic guinea pig(100713508) zona pellucida glycoprotein 2 (sperm receptor)
- naked mole-rat(101706160) zona pellucida glycoprotein 2 (sperm receptor)
- Domestic Rabbit(100009069) zona pellucida glycoprotein 2 (sperm receptor)
- sheep(101123598) zona pellucida glycoprotein 2 (sperm receptor)
- chicken(427006) zona pellucida glycoprotein 2 (sperm receptor)
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