O8139

Opiorphin

≥98% (HPLC), lyophilized powder

• Empirical Formula (Hill Notation): C₂₉H₄₈N₁₂O₈
• CAS Number: 864084-88-8
• Molecular Weight: 692.77
• UNSPSC Code: 12352200

Properties

• Assay: ≥98% (HPLC)
• form: lyophilized powder
• storage condition: desiccated; protect from light
• color: white
• solubility: H₂O: soluble >1 mg/mL
• storage temp.: −20°C

Description

Amino Acid Sequence

Gln-Arg-Phe-Ser-Arg

Biochem/physiol Actions

Opiorphin is a natural analgesic, dual action pain killer; six times stronger than the opiate morphine.

Opiorphin is a natural analgesic, secreted into human saliva. Opiorphin demonstrates dual-inhibitory potency on the enkephalin-inactivating ectopeptidases human NEP (hNEP) and human AP-N (hAP-N). As an analgesic, Opiorphin is six times stronger than the opiate morphine. Opiorphin is closely related to the rat sialorphin peptide, which is an inhibitor of pain perception and acts by potentiating endogenous micro- and δ-opioid receptor-dependent enkephalinergic pathways. In rat studies, Opiorphin suppressed pain sensation for both chemical-induced inflammation and acute physical pain. In both cases, the administered dose of 1 mg/kg provided the same painkilling power as 3-6 mg/kg of morphine.

Specifications

The peptide content is 78.9%

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves