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S6760

Span® 80

nonionic surfactant

Synonym(s):

Sorbitane monooleate, sorbitan oleate

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About This Item

CAS Number:
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12161900
EC Number:
215-665-4
MDL number:
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Quality Level

mol wt

428.62 g/mol

concentration

≥60% (GC)

HLB

4.3

application(s)

microbiology

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/b10-9-/t20-,21+,23+,24+/m0/s1

InChI key

NWGKJDSIEKMTRX-AAZCQSIUSA-N

General description

Span® 80 is a nonionic surfactant. [1]

Application

Span® 80 has been used in a study to assess transfersomes as a transdermal delivery system for sertraline. [2] It has also been used in a study to investigate the dominant factors affecting the stability of nanoemulsions through the use of artificial neural networks (ANNs). [3]

Other Notes

Fatty acid composition: Oleic acid (C18:1) ≤ 60%; balance primarily linoleic (C18:2), linolenic (C18:3) and palmitic (C16:0) acids.

Legal Information

Span is a registered trademark of Croda International PLC

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This Item
855488.4012309569
application(s)

microbiology

application(s)

-

application(s)

-

application(s)

-

HLB

4.3

HLB

-

HLB

-

HLB

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

mol wt

428.62 g/mol

mol wt

428.60 g/mol

mol wt

-

mol wt

428.60 g/mol

concentration

≥60% (GC)

concentration

-

concentration

-

concentration

-


Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves



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Ankit Gupta et al.
Scientia pharmaceutica, 80(4), 1061-1080 (2012-12-25)
The aim of the present study was to investigate transfersomes as a transdermal delivery system for the poorly soluble drug, sertraline, in order to overcome the troubles associated with its oral delivery. Different transfersomal formulations were prepared with non-ionic surfactant
Hoang Hirschberg et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(1-2), 1-7 (2012-02-15)
In the search for an optimal approach for the transcutaneous immunization (TCI) of hepatitis B surface antigen (HBsAg), two vesicle formulations, L595 vesicles (composed of sucrose-laurate ester and octaoxyethylene-laurate ester) and sPC vesicles (composed of soybean-phosphatidylcholine and Span-80) were prepared
Jean-François Cotte et al.
International journal of pharmaceutics, 436(1-2), 233-239 (2012-06-21)
Mass spectrometry (MS) and high performance liquid chromatography coupled to mass spectrometry (HPLC-MS) techniques were developed to characterize two surfactants, cetheareth-12 and sorbitan oleate, used to manufacture AF03, an emulsified oil-in-water (O/W) adjuvant. MS was first used to characterize the



Global Trade Item Number

SKUGTIN
S6760-1L04061837609398
S6760-250ML04061837609404

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. we bought Span 80 (Cat no S6760- 250 ml) for lab purpose. Please let us know its density in g/mL

    1 answer
    1. The density for this product is 0.986 g/mL at 25°C.

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