- Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.
Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.
Journal of inorganic biochemistry (2011-11-22)
Joseph Lemire, Vasu D Appanna
PMID22099161
ABSTRACT
Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis
Aluminum, IRMM®, certified reference material, 1.0 mm foil
Aluminum, IRMM®, certified reference material, 1.0 mm wire
Aluminum, mesh, 900x900mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh
Aluminum, rod, 44mm, diameter 77.5mm, as drawn, 99.999%
Aluminum, tube, 500mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%
Aluminum, rod, 200mm, diameter 12.7mm, 99%
Aluminum, tube, 1000mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%
Aluminum, tube, 1000mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%
Aluminum, rod, 100mm, diameter 25.0mm, as drawn, 99.999%
Aluminum, wire reel, 100m, diameter 0.25mm, as drawn, 99.5%
Aluminum, tube, 500mm, outside diameter 0.55mm, inside diameter 0.4mm, wall thickness 0.075mm, as drawn, 99.5%
Aluminum, tube, 0.1m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
Aluminum, insulated wire, 20m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%
Aluminum, rod, 100mm, diameter 12.7mm, 99%
Aluminum, tube, 200mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%
Aluminum, microfoil, disks, 25mm, thinness 0.0075μm, specific density 1.84μg/cm2, permanent mylar 3.5μm support, 99.999%
Aluminum, wire reel, 500m, diameter 0.25mm, as drawn, 99.5%
Aluminum, wire reel, 1m, diameter 3.0mm, as drawn, 99.999%
Aluminum, wire reel, 20m, diameter 2.0mm, as drawn, 99.999%
Aluminum, wire reel, 10m, diameter 0.5mm, as drawn, 99.5%
Aluminum, rod, 100mm, diameter 20.0mm, as drawn, 99.999%
Aluminum, insulated wire, 1m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%
Aluminum, wire reel, 500m, diameter 0.30mm, as drawn, 99.5%
Aluminum, wire reel, 200m, diameter 0.25mm, as drawn, 99.95+%