Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Dalton transactions (Cambridge, England : 2003) (2012-08-15)

Živadin D Bugarčić, Jovana Bogojeski, Biljana Petrović, Stephanie Hochreuther, Rudi van Eldik

ABSTRACT

A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.

MATERIALS

Product Number

Brand

Product Description

GF57762399

Platinum, foil, not light tested, 50x50mm, thickness 0.005mm, as rolled, 99.95%

GF85632408

Platinum, foil, 6mm disks, thickness 0.025mm, as rolled, 99.99+%

GF55534046

Platinum, foil, 0.05m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF15087203

Platinum, foil, 0.1m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%

GF20699994

Platinum, foil, 4mm disks, thickness 0.004mm, as rolled, 99.95%

GF55213657

Platinum, wire reel, 0.1m, diameter 0.175mm, as drawn, 99.95%

GF96551354

Platinum, foil, 10mm disks, thickness 0.0075mm, as rolled, 99.95%

GF05432936

Platinum, foil, 0.05m coil, thickness 0.030mm, coil width .7mm, as rolled, 99.95%

GF47354508

Platinum, wire reel, 0.1m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%

GF87499906

Platinum, foil, 6mm disks, thickness 0.004mm, as rolled, 99.95%

GF99566410

Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.99+%

GF73706058

Platinum, foil, 10mm disks, thickness 0.0125mm, as rolled, 99.95%

GF68611237

Platinum, foil, 0.2m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF83202083

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GF85102837

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GF02450180

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GF52591462

Platinum, foil, 4mm disks, thickness 0.0075mm, as rolled, 99.95%

GF17993368

Platinum, foil, 10mm disks, thickness 0.125mm, as rolled, 99.95%

GF02102948

Platinum, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.99+%

GF76687105

Platinum, wire reel, 0.5m, diameter 0.15mm, annealed, may be used as one component of a thermocouple, 99.99%

GF60594442

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GF29981199

Platinum, wire reel, 0.1m, diameter 0.002mm, wollaston, 99.9%

GF25487387

Platinum, wire reel, 0.2m, diameter 1.0mm, hard, 99.95%

GF36280021

Platinum, foil, 0.2m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%

GF03383704

Platinum, wire reel, 0.1m, diameter 0.25mm, annealed, may be used as one component of a thermocouple, 99.99%

GF84685236

Platinum, foil, 6mm disks, thickness 0.005mm, as rolled, 99.95%

GF61623064

Platinum, wire reel, 0.1m, diameter 0.8mm, annealed, may be used as one component of a thermocouple, 99.99%

GF12344677

Platinum, foil, not light tested, 50x50mm, thickness 0.0015mm, as rolled, 99.95%

GF41858309

Platinum, foil, 0.2m coil, thickness 0.05mm, coil width 1mm, as rolled, 99.99%

GF45803897

Platinum, wire reel, 0.1m, diameter 1.0mm, hard, 99.95%