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Smart Nanofiber Meshes as a Local Drug Delivery Platform
Professor Mitsuhiro Ebara provides insights on several types of smart nanofiber mesh systems that have been explored for different drug delivery purposes.
Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids
The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1Mn
Layer-by-Layer (LbL) Assembly, A "Gentle Yet Flexible" Method Toward Functional Biomaterials
Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the
Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique
Polyelectrolyte Multilayer Films and Membrane Functionalization
We present an article that discusses two applications in particular; first, using these layers as polyelectrolyte membranes to control permeability.
Fluorescent Microparticles and Nanobeads
Fluorescently labeled microparticles are useful as standards in flow cytometry, confocal laser scanning microscopy, and with light scattering instruments..
RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering
Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.
Functional Biomaterials Synthesized by Double-Head Polymerization Agents
Over the past two decades, the rapid advance of controlled living polymerization (CLP) techniques.
Degradex® Microspheres and Nanoparticles for Drug Delivery Research and Formulation Development
Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.
Polymersomes for Drug Delivery
The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.
Functionalized PEI and Its Role in Gene Therapy
Gene therapy has become one of the most discussed techniques in biomedical research in recent years.
Chitosan-based Biomaterials
Chitin, a natural polysaccharide, is the second most abundant natural biopolymer in the world, after cellulose.
Electrospun Nanofibers for Drug Delivery Systems
Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
Delivery of Nucleic Acids Using Polymers
Delivery of Nucleic Acids Using Polymers
Smart Oligonucleotide Delivery by Multifunctional Block Copolymers
Kanjiro Miyata (The University of Tokyo, Japan) provides insights on the rational design of polymeric materials for “smart” oligonucleotide delivery.
Photo-Crosslinkable Gelatin Hydrogel: Versatile Materials for (High Resolution) Additive Manufacturing
Discussion of synthetic modifications to gelatin, improving the three-dimensional (3D) print resolution, and resulting material properties.
Designing Temperature and pH Sensitive NIPAM Based Polymers
Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.
Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation
Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.
Microfluidics for Nanoencapsulation of Nucleic Acids Using Polymeric Carriers
Microfluidic assembly can efficiently overcome the general disadvantages of polyamine nanoencapsulation of nucleic acids, such as a less defined morphology and composition, polydispersity, and poor reproducibility.
NanoFabTx™ Nanoparticle and mRNA Liposome Formulation Using the NanoAssemblr®
NanoFabTX drug delivery formulation kits and lipids mixes for mRNA, nucleic acid, and small molecule delivery in lipid nanoparticles, liposomes and polymeric nanoparticles prepared using Precision NanoSystems microfluidic NanoAssemblr
Protein- and Peptide- Polymer Conjugates by RAFT Polymerization
The modification of biomacromolecules, such as peptides and proteins, through the attachment of synthetic polymers has led to a new family of highly advanced biomaterials with enhanced properties.
Polydiacetylene Nanotubes (PDNTs): Nanotubes Based On Lipid Diacetylene Materials
Polydiacetylene nanotubes (PDNTs) are self-assembled diacetylene nanotubes comprised of cross-linked, conjugated double and triple bonds.
Quantum Dots
Quantum dots are tiny particles or nanocrystals of a semiconducting material with diameters in the range of 2-10 nanometers.
Gold Nanoparticles: Properties and Applications
Gold (Au) nanoparticles have tunable optical and electronic properties and are used in a number of applications including photovoltaics, sensors, drug delivery & catalysis.
Functional RAFT Polymers for Biomedical Applications
Reversible addition–fragmentation chain transfer (RAFT) polymerization is rapidly moving to the forefront in construction of drug and gene delivery vehicles.
Silicon Carbide: The Return of an Old Friend
In recent years silicon carbide, SiC, has re-emerged as a vital technological material that is crucial in many materials and engineering applications.
Rational Design of ECMs Toward Cancer Immunotherapy
Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.
Approaches to the design of lipid-based nanocarriers
LNPs are ideal carriers for mRNA drugs, as evident from the two FDA-approved SARS-CoV-2 vaccines. However, efficient LNPs need further research on ionizable lipid selection, formulation, and administration. This review examines lipid usage, ionizable lipid selection, and LNP design for
Drug Delivery FAQs
Find answers to common questions about drug delivery. Review important points about encapsulation efficiency and loading capacity.
Preparation of Chitosan Microparticles by Spray Drying
Carcinogenic compounds in elastomers: 1,3-butadiene and isoprene used in elastomer manufacturing, classified as carcinogenic by IARC.
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