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Merck

ACHE

acetylcholinesterase

同義詞:
ACEE, ARACHE, N-ACHE, YT
物種:
UniProtKB ID:
基因 ID:
  • Human(43) Summary: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
  • Mouse(11423) acetylcholinesterase
  • Rat(83817) acetylcholinesterase
  • domestic guinea pig(100422792) acetylcholinesterase
  • sheep(101123006) acetylcholinesterase
  • cow(540446) acetylcholinesterase
  • domestic cat(493674) acetylcholinesterase
  • Zebrafish(114549) acetylcholinesterase
  • chicken(396388) acetylcholinesterase
  • naked mole-rat(101705724) acetylcholinesterase
  • dog(489828) acetylcholinesterase

Custom & Knockdown Gene Products

Small Molecule - Activator

產品編號
描述
物種
2-吡啶醛肟甲氯, ,
物種
human
氯解磷定, United States Pharmacopeia (USP) Reference Standard,
物種
human

Small Molecule - Agonist

產品編號
描述
物種
氯化乙酰硫代胆碱, ≥99% (TLC), powder,
物種
human

Antibodies

產品編號
描述
物種活性
應用
Anti-Acetylcholinesterase Antibody, clone AE-1, clone AE-1, Chemicon®, from mouse,
物種活性
bovine, canine, chicken, guinea pig, human, monkey
應用
ELISA
immunohistochemistry

immunoprecipitation (IP)
Anti-ACHE antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物種活性
cat, human, mouse, rabbit, rat
應用
ELISA
flow cytometry

immunofluorescence

western blot
Monoclonal Anti-ACHE antibody produced in mouse, clone 2C3, purified immunoglobulin, buffered aqueous solution,
物種活性
human, mouse
應用

Small Molecule - Inhibitor

產品編號
描述
物種
盐酸多奈哌齐, ≥98% (HPLC),
物種
human
东莨菪内酯, ≥99%,
物種
human
溴吡斯的明, ,
物種
human
新斯的明, ≥98% (HPLC and titration), powder,
物種
human
Galanthamine hydrobromide from Lycoris sp., ≥94% (HPLC),
物種
human

Kits

產品編號
描述
物種
乙酰胆碱酯酶活性检测试剂盒, sufficient for 100 colorimetric tests,
物種
mouse, human

Proteins

產品編號
描述
物種
乙酰胆碱酯酶 人, recombinant, expressed in HEK 293 cells, lyophilized powder, ≥1,000 units/mg protein (BCA),
物種
human
乙酰胆碱酯酶 来源于人类红细胞, buffered aqueous solution, ≥500 units/mg protein (BCA),
物種
human