PYGL
phosphorylase, glycogen, liver
同義詞:
GSD6
物種:
Human PYGL (5836), Mouse Pygl (110095), Rat Pygl (64035), sheep PYGL (554320), chicken PYGL (378909), Horse PYGL (100066726), Zebrafish pygl (493916), naked mole-rat Pygl (101723998), cow PYGL (505472), dog PYGL (403738) ...更多
UniProtKB ID:
基因 ID:
- Human(5836) Summary: This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]
- Mouse(110095) liver glycogen phosphorylase
- Rat(64035) phosphorylase, glycogen, liver
- sheep(554320) phosphorylase, glycogen, liver
- chicken(378909) phosphorylase, glycogen, liver
- Horse(100066726) phosphorylase, glycogen, liver
- Zebrafish(493916) phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)
- naked mole-rat(101723998) phosphorylase, glycogen, liver
- cow(505472) phosphorylase, glycogen, liver
- dog(403738) phosphorylase, glycogen, liver
- domestic cat(101089364) phosphorylase, glycogen, liver
- domestic guinea pig(100721433) phosphorylase, glycogen, liver
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Antibodies
產品編號
描述
物種活性
應用
Anti-PYGL antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
western blot
Small Molecule - Inhibitor
產品編號
描述
物種