單株抗體藥物發現始於識別功能性治療靶點，並評估其在目標疾病中的作用。隨後需闡明該靶點所涉及的分子機制。所有靶點均應具備可成藥性，且能被潛在治療藥物調控。隨著各種基因組工程與雜交瘤技術的出現，這些早期階段已得到簡化，這些技術可用於生物治療性抗体的靶點與先導化合物發現。
搶佔先機
發掘、篩選並驗證與疾病密切相關的新靶點。藥物研發初期所做的抉擇，將直接決定專案成敗。識別最合適且具藥物開發潛力的靶點是成功的關鍵。我們提供完整的基因組級、通路特異性及蛋白質家族靶向篩選工具組，助您高效完成靶點發現。
• 功能基因組學篩選工具用於標靶識別
• 體外工具用於標靶驗證
• 單株抗體生產 •
純化
• 篩選與選擇單株抗體候選物
• 先導化合物優化
• 前臨床模型
• 藥代動力學/藥效動力學與免疫原性
相關資源
- Pooled CRISPR Screening
CRISPR lentiviral products are powerful research tools for the discovery of novel targets essential to human health and disease. As a world leader in the production of lentiviral libraries, we design and build custom pools to any specifications.
- MULTI-seq Sample Multiplexing for Single Cell Analysis
scRNA-seq is a powerful tool to analyze gene expression at the single-cell level. MULTI-seq was developed to multiplex sample types, allowing for multiple samples to be pooled together in the same single-cell analysis workflow.
- The ELISpot Assay Enables Functional Analysis of Cellular Immunology
Recent improvements to the design of multiwell microplates, including use of membranes with reduced background fluorescence, have bolstered the widespread application of ELISpot assays.
- Designing Peptides
When selecting peptides for custom synthesis, several important factors should be considered during the design process. These considerations include sequence length, solubility and sequence stability.
- Protein Expression Systems
An overview of bacterial, yeast, insect, and mammalian protein expression systems and their various advantages and disadvantages.
- Primary Cell Culture Basics
A comprehensive overview of animal and human primary cell lines and media and how they are used in cell culture applications.
- Antibody Purification Using Protein A, Protein G, or Protein L Agarose
Protocols for batch antibody purification using Protein A, Protein G, or Protein L agarose.
- Antibody Purification Using Protein A-based Chromatography
Purification options using Protein A sepharose chromatography media, from binding to elution.
相關類別
使用我們的CRISPR基因編輯工具，實現目標基因的敲除、敲入、敲除或過量表達。
適用於細胞系、原代細胞、類器官及進階細胞模型的細胞培養基。
實驗室規模、製程規模及工業規模的抗體色譜純化。
若要繼續閱讀，請登入或建立帳戶。
還沒有帳戶？為便利客戶閱讀，此頁面中文以機器翻譯完成。雖然我們已盡力確保機器翻譯的準確性，但機器翻譯並非完美。如果您對機器翻譯的內容不滿意，請參考英文版本。