1.04672

胆固醇

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, NF

• 同義詞: 3β-羟基-5-胆甾烯, 5-胆甾烯-3β-醇
• 經驗公式（希爾表示法）: C₂₇H₄₆O
• CAS 編號: 57-88-5
• 分子量：: 386.65
• UNSPSC Code: 12352104
• Beilstein/REAXYS Number: 1915888
• MDL number: MFCD00003646

屬性

• biological source: synthetic
• Quality Segment: 500
• agency: BP, ChP, JP, NF, Ph. Eur.
• product line: EMPROVE^® EXPERT
• form: powder
• bp: 360 °C (lit.)
• mp: ~141 °C, 147-149 °C (lit.)
• density: 1.067 g/mL at 25 °C (lit.)
• suitability: suitable for (Suitable for formulation and manufacturing use)
• application(s): advanced drug delivery; controlled release; liquid formulation; mRNA manufacturing; parenterals; pharmaceutical
• storage temp.: 2-25°C
• SMILES string: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChI key: HVYWMOMLDIMFJA-DPAQBDIFSA-N

描述

General description

A GMP-scalable process which yields a high-quality lipid is essential to lipidic drug product development and manufacturing. We are highly specialized in synthesizing top-quality GMP lipids for pharmaceutical applications and gene therapy, focusing on tailored manufacturing to meet your specific needs. We also offer an off-the-shelf catalog with optimized stability, solubility, and handling characteristics.
Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Cholesterol is a major component of all biological cell membranes and is used as a stabilizer of lipid bilayers in many lipid-based formulations for the delivery of different APIs, such as small molecules and nucleic acids.

Synthetic cholesterol, Ph Eur, BP, ChP, JP, NF is ultra-pure and therefore suitable for divers formulations applications. Due to low batch to batch variability, very high purity, and lack of biological components, this product is optimal for highly sensitive applications such as nucleic acid delivery.

With a newly optimized manufacturing process, this product is available in quantities from grams to tons to support your development progress. A dual sourcing option is also possible.

Biochem/physiol Actions

所有生物膜的主要成分；总脑脂质中约25%为胆固醇。

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

SyntheChol is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The substance 1.04672 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

安全資訊

• 存儲類別/等級: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable