Buchwald G6 precatalysts are oxidative addition complexes that enhance palladium-catalyzed cross-coupling reactions. They provide higher reactivity, stability, and simplified synthesis, facilitating the formation of various bonds with improved selectivity and fewer byproducts.
G3 and G4 Buchwald palladium precatalysts are the newest air, moisture, and thermally stable crossing-coupling complexes used in bond formation for their versatility and high reactivity.
Professor Stephen Buckwald and the Buchwald group have developed a series of highly active and versatile palladium precatalysts and biarylphosphine ligands used in a variety of cross-coupling reactions.
Kitalysis high-throughput screening kits are designed for Buchwald-Hartwig amination reactions. These kits contain air and moisture-stable preformed catalysts, facilitating efficient scale-up of catalytic reactions.
We offer an extensive portfolio of nickel and palladium catalysts to aid in the creation of C–C, C–N, and C–O bonds through common cross-coupling reactions.
Biscoe MR, Fors BP, Buchwald SL. 2008. A New Class of Easily Activated Palladium Precatalysts for Facile C−N Cross-Coupling Reactions and the Low Temperature Oxidative Addition of Aryl Chlorides. J. Am. Chem. Soc.. 130(21):6686-6687.https://doi.org/10.1021/ja801137k
2.
Kinzel T, Zhang Y, Buchwald SL. 2010. A New Palladium Precatalyst Allows for the Fast Suzuki−Miyaura Coupling Reactions of Unstable Polyfluorophenyl and 2-Heteroaryl Boronic Acids. J. Am. Chem. Soc.. 132(40):14073-14075.https://doi.org/10.1021/ja1073799
3.
Bruno NC, Tudge MT, Buchwald SL. Design and preparation of new palladium precatalysts for C–C and C–N cross-coupling reactions. Chem. Sci.. 4(3):916-920.https://doi.org/10.1039/c2sc20903a
4.
King RP, Krska SW, Buchwald SL. 2021. A Ligand Exchange Process for the Diversification of Palladium Oxidative Addition Complexes. Org. Lett.. 23(15):6030-6034.https://doi.org/10.1021/acs.orglett.1c02101
5.
McCann SD, Reichert EC, Arrechea PL, Buchwald SL. 2020. Development of an Aryl Amination Catalyst with Broad Scope Guided by Consideration of Catalyst Stability. J. Am. Chem. Soc.. 142(35):15027-15037.https://doi.org/10.1021/jacs.0c06139
6.
Drance MJ, Wang S, Gembicky M, Rheingold AL, Figueroa JS. 2020. Probing for Four-Coordinate Zerovalent Iron in a π-Acidic Ligand Field: A Functional Source of FeL4 Enabled by Labile Dinitrogen Binding. Organometallics. 39(18):3394-3402.https://doi.org/10.1021/acs.organomet.0c00487
