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Vaccine Manufacturing: Process Development and Expertise

Vaccine Development and Manufacturing Capabilities

Vaccines are among the most cost-effective health interventions against pathogens and other infectious diseases, saving millions of lives annually while improving quality of life for countless others. Growing global demand, however, poses severe challenges for vaccine manufacturers. Each new pathogen or outbreak adds to the variety of vaccine types and manufacturing methods needed, preventing establishment of robust processing templates that could improve overall effectiveness, safety, and affordability.

From a manufacturing perspective, many factors are critical to accelerating vaccine production and meeting performance goals. These include predictable scale-up, optimal upstream productivity, robust impurity removal, maximized downstream recovery, speed to clinic, patient safety, and regulatory compliance. Achieving process improvements can drive success for all of the vaccine development platforms described below, but innovative technologies and a high level of application expertise are required.

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VACCINE MANUFACTURING PLATFORMS

Virus-Based Vaccines

Virus-like Particle (VLP) Vaccines

Viral Vector Vaccines

Plasmid DNA Vaccines

mRNA Vaccines

Conjugated Polysaccharide Vaccines

Cell Harvest, Lysis, Neutralization and Clarification of Plasmid DNA (pDNA) for mRNA, plasmid-based DNA Vaccines, and Viral Vector applications
An overview of the cell harvest, lysis, neutralization, and clarification steps used for pDNA purification along with case study and practical advice.
Choosing the Optimal Cell Culture Media for Vaccine Production
Choosing the Optimal Cell Culture Media for Vaccine Production
Manufacturing Strategies for mRNA Vaccines and Therapeutics
mRNA technology uses non-viral delivery systems and offers a great deal of versatility. Delivery of an mRNA into the cytosol of a cell can induce the production of a target protein which can function as a therapeutic or prophylactic, act as an antigen to trigger an immune response for vaccination purposes, replace a defective protein or activate an anti-tumor response.
mRNA Synthesis for the Development of Vaccines and Therapeutics
Understand how mRNA vaccines induce immunity. and read how synthetic mRNA is prepared for vaccine immunogens and other biopharmaceuticals. Find reagents for synthesis of mRNA.
Use of Benzonase® Nuclease to Prevent Clumping of Stored Peripheral Blood Mononuclear Cells (PBMCs) During Vaccine Evaluation
Inclusion of Benzonase® Nuclease in PBMC thawing buffer prevents cell clumping and allows implementation of PBMC cryopreservation.
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Related Resources

e-Book: Enabling Capabilities & Solutions for all Vaccine Platforms
Brochure: Vaccine Bioprocessing Handbook
Brochure: Enabling Vaccines Production - Solving Challenges Together
Biopharmaceutical Applications Guide
White Paper: Developing an Accelerated and More Cost-Effective Single-Use Adenoviral Vector Vaccine Manufacturing Process

White Paper: How Pandemics and Outbreaks Have Influenced the Adoption of Single-use Vaccine Manufacturing
Brochure: Flexible Manufacturing of Vaccine
White Paper: Vaccine Manufacturing - Collaboration Helps to Overcome Vaccine Process Challenges

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