Bioreactors for Fed-Batch and Perfusion Upstream Processes
Future-Proof Your Process with Modular Flexibility Today
The Mobius® iFlex Bioreactor takes modular flexibility, scalability, ergonomics, and convenience to the next level while adding next-generation performance and productivity.
Pipelines are diversifying, new therapeutic modalities are emerging, and demands for efficiency and productivity are increasing. To respond to these opportunities and challenges, today and in the future, manufacturers need the upstream flexibility of a traditional fed-batch bioreactor system with the ability to evolve to perfusion processes.
Access Next Generation Benefits for your Upstream Workflow Today
Mobius® iFlex Bioreactors are scalable from 50 L to 2000 L and incorporate innovative features for cell culture, including:
- A modular design, with a bioreactor vessel, fed-batch tower, perfusion tower, and control station that can be combined to suit your upstream process needs
- 5:1 turndown ratio for 200 L – 2000 L bioreactors (3.3:1 for 50 L), for flexible seeding and cell growth strategies
- An optimized bottom-mounted impeller design allows fast mixing times and higher power density, minimizing tip speed and mechanical shear
- An internal X-baffle for superior homogeneous mixing
- Three different spargers integrated in all single-use bag assemblies, providing unparalleled oxygen transfer.
Discover the Mobius® iFlex Bioreactor for Fed-Batch and Perfusion Culture
The Mobius® iFlex Bioreactor is a next-generation, single-use, modular bioreactor meticulously engineered for optimal performance in both batch and perfusion processes. It offers flexibility to integrate into a standard DeltaV-based automation or into your automation of choice.
In its fed-batch configuration, the system is composed of a bioreactor vessel, a fed-batch tower, and a control station, integrating all the sensors your upstream process requires for monitoring and control of critical process parameters. The bioreactor vessel and the fed-batch tower can be configured to suit your specific process requirements and offers the scalability, robustness, and reliability you expect from Mobius® Bioreactors.
Seamless Transition from Batch to Perfusion Processes
As your processes evolve toward intensified and continuous upstream processes, you can seamlessly transition into a perfusion process by adding a perfusion tower.
Working in unison with our Cellicon® filter assemblies, the Mobius® iFlex Bioreactor enables perfusion processes with a unique, ergonomic single-use design that supports ultra-high cell densities. To support high cell densities which require increased oxygen, our innovative single-use spargers, X-baffle and bottom-mounted impeller work together to provide unparalleled oxygen transfer with minimal cell shear.
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Related Product Resources
- Datasheet: Mobius® iFlex Bioreactor
The Mobius® iFlex Bioreactor is a scalable family of next generation high-performance single-use modular bioreactors for fed-batch and perfusion processes, ranging from 50 L to
2000 L, and suitable for process development and commercial manufacturing. - Scalability and Performance Guide: Mobius® iFlex Bioreactors
The Mobius® iFlex Bioreactor family offers single-use, stirred tank systems designed to support both traditional fed-batch and perfusion intensified cell culture applications. Performance attributes of the impeller, spargers, Ultimus® film and sensors were characterized to determine the effective design space and operating range for accurate process monitoring and control.
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A homogenous environment and a rapid response to changing conditions are key requirements for a bioreactor. It is important to choose a method that will provide the highest quality data and enable effective cross-system comparison of results.
- Ultimus® Film – A Single-use Bioprocessing Film Engineered for Strength and Leak Prevention
Ultimus® Film is an innovative single-use bioprocessing film offering strength and leak resistance, available in Mobius® 3D bioprocess bags, it provides a stronger, more durable solution for your single-use manufacturing challenges.
- Biopharma 4.0: Digitalized, Intensified, and Continuous Bioprocessing
Bioprocessing 4.0 is the convergence of advanced upstream and downstream bioprocessing technologies, PAT, data analytics, automation, and control software for the biomanufacturing facility of the future. The BioContinuum™ Platform provides these building blocks and expertise to help you gain new levels of performance and productivity.
- Process Analytical Technologies (PAT)
Process Analytical Technology (PAT) is a regulatory framework initiated by the United States’ Food and Drug Administration (FDA) that encourages innovation in pharmaceutical development, manufacturing, and quality assurance.
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