MilliporeSigma

Get Up to Speed in Your UF/DF

With plug ‘n play and linearly scalable Pellicon® Capsules for gene therapy and vaccine production.

Experience Superior Flux Wrapped in a Plug ‘N Play Format to Save Time and Achieve Linear Scalability in Your Ultrafiltration/Diafiltration Process

Our Pellicon® Capsules are a true single-use solution for your TFF challenges. Designed for efficient single-use UF/DF, the Pellicon® Capsule is a first-of-its-kind spiral-wound TFF filter engineered to provide you with performance consistency and linear scalability for reliable process development and predictable scale-up at any stage of your gene therapies and vaccines.

Take Advantage of our Special Offer!

Its plug ‘n play holderless format provides fast and easy installation, as well as self-containment for those processes requiring additional safety. The capsules are gamma sterilized and can integrate into our TFF systems from process development to process scale. With optimum feed channel design, the capsules perform with high flux to meet your concentration targets with speed.

  • Plug ‘n play holderless design for faster installation and safer removal
  • True single-use, gamma sterilized capsule that is ready to use in minutes and enables closed processing
  • Superior flux with optimum feed channel screen for faster processing and higher achievable concentration factors than hollow fibers
  • Optimum recovery with ultra-low binding Ultracel® membrane ideal for high value therapeutics
  • Linearly scalable with the same performance as our Pellicon® cassettes for reliability across all scales
Pellicon® Capsule chart

Comparison of initial operating flux performance for flatsheet and hollow fiber filters and operating systems for 100 and 300 kDa NMWL. For TMP control (one pump), initial flux is the flux at optimal TMP. For permeate control (two pump), initial flux is 50% of the critical flux. The higher flux provided by capsules and cassettes result in faster processing time or reduced membrane area requirements.

Interested in Pellicon® Capsules for mAb and ADC production?

BUY TWO, GET 50% OFF BY JULY 15 2023!

Inventory is Limited. Pellicon® Capsules size 0.1 m2 with Ultracel® membrane 100 kD and 300 kD only available for this offer.

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Related Technical Resources

Product Overview: Ultrafiltration/Diafiltration (UF/DF) of Adeno-Associated Viruses (AAV) with Pellicon® Capsules and Pellicon® XL 50 Cassettes
Technical Article: Tangential Flow Filtration in Downstream Bioprocessing
Technical Article: Single-Pass Tangential Flow Filtration Implementation and Scaling
Technical Article: Tangential Flow Filtration in the Antibody Drug Conjugate (ADC) Manufacturing Process

Podcast Transcript: Interview - Shear ignorance? Think again: breaking the perception of shear within viral vector manufacturing
Application Note: Pellicon® Capsules versus Hollow Fibers for Ultrafiltration/Diafiltration (UF/DF) in Viral Gene Therapy Manufacturing
Evaluation of TFF Operating Control Strategies and Scalability for Viral Vector Process Development

Related Applications

Gene Therapy Manufacturing
Growing use of gene therapies is driving rapid innovation in an evolving global market. Manufacturers bringing new gene therapies to life face complex challenges, requiring an experienced partner capable of integrating vector manufacturing, testing, safety, process development, and regulatory compliance.
Viral Vector Downstream Processing
Demand for new gene therapies is challenging manufacturers to accelerate development. By replacing legacy purification technologies with more scalable alternatives, downstream operations can produce greater economies while delivering higher yield and throughput.
Vaccine Manufacturing
From early phase development, through downstream purification to large scale vaccine production: learn more about vaccine process development and application expertise.
mRNA Manufacturing and Formulation
Find high-quality raw materials and products for mRNA manufacturing and formulation. Our mRNA and lipid CDMO service and testing services can help enable your fast turnaround times.

Related Services

Viral Vector CTDMO Services
Our viral and gene therapy manufacturing site in Carlsbad, California has produced over 1,000 batches of virus, meeting rigorous timelines for more than 20 years with a complete range of services, a state-of-the-art cGMP facility, and deep regulatory understanding.

Related Product Categories

Ultrafiltration & Diafiltration
Ultrafiltration & diafiltration are important steps throughout bioprocessing to increase capacity, concentration, and recovery. Increasingly, single-pass tangential flow filtration (SPTFF) is being implemented in continuous or intensified processes to reduce in-line volumes.
Tangential Flow Filtration Holders & Systems
Our tangential flow (crossflow) filtration systems are engineered for low hold-up volume, maximum volume concentration, and optimal product recovery in single-use and multi-use applications from process development to large-scale manufacturing, with compatible holders available for expendables.
Tangential Flow Filtration Devices
From single-use to multi-use, our tangential flow filtration products are ideal for a range of high-value applications – consistently delivering purity assurance at every stage and scale throughout the lifecycle of your drug products, including mAbs, ADCs, plasma IgG, insulin, vaccines, and viral vectors.
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