MilliporeSigma

Synple Chem

Automated Chemical Synthesis Platform


SYNTHESIS MADE SYNPLE - Synple Automatic Synthesizer & Reagent Cartridges

As a leading supplier of reagents and tools for chemical synthesis, we are continuously expanding our portfolio of innovative products to enhance and facilitate your research. Now, we’ve partnered with Synple Chem to bring you the ingenious Synple 2: a fully automated organic chemical synthesis system that is digitized and pre-programmed to generate your research products for you. Say goodbye to manual reactions. Discover how the incredible speed and accuracy of Synple 2 can boost your lab’s productivity and accelerate your discovery.


Key Features

5 x More efficient

  • Fully automated organic synthesis
  • 5 minutes to set up
  • Frees your time to focus on more important experiments

Accurate & convenient

  • Optimized reaction, no risk of human error
  • Compact size (W 26 cm, H 36 cm, D 49 cm)
  • Fast and easy orders through our web shop

70% Cost savings

  • Considerably more economical than manual chemical synthesis due to lower personnel and reagent costs

No special training

  • Easy to use, requires no detailed chemistry knowledge
  • Modular system for a range of reactions at the press of a button

Enhanced safety

  • Fully enclosed reaction
  • User never exposed to chemicals
  • Complies with latest safety standards

90% Less waste

  • Fully optimized reaction sequence
  • Uses minimum reagents and solvents, greatly reducing chemical waste

Synthesis in 4 Simple Steps

The platform consists of the Synple 2 chemical synthesizer and a range of reagent cartridges for different reactions. Simply add your starting material and the appropriate reagent cartridge to the synthesizer and press a button. The product is automatically generated, isolated and purified with only minutes of hands-on time and is running autonomously by itself during the reaction – not hours as in manual synthesis.

1. Set Up Your Reaction

Set Up Your Reaction

    2. Start Synthesis

    Start synthesis

      3. Let Synple Work

      Let Synple Work

        4. Collect Your Product

        Collect Your Product

          1. Scan the pre-filled reagent cartridge and insert it into the synthesizer, then add your starting material.

          2. Simply press the START button on the synthesizer.

          3. The synthesizer generates, isolates, and purifies your product in minutes.

          4. Synple then performs an automated washing sequence to prepare for your next synthesis.


          How Synple Works

          Synple 2 Synthesizer

          The Synple 2 synthesizer: contains two syringe pumps, and two rotary valves, in addition to a sample holder, cartridge holder, an RFID chip scanner, and a touchscreen. During synthesis, reactions can occur in the cartridge itself, or in the reaction vial.

          Synple Cartridges

          Synple cartridges: are offered for a variety of reactions. Each cartridge contains all the reagents required to generate, isolate, and purify your product, as well as an RFID chip which is encoded with the reaction method.

          Automatic Synthesis

          5-Minute setup: Scan the cartridge on the synthesizer to automatically load the appropriate reaction method. Although the provided methods are suitable for a broad range of starting materials, you may adjust certain parameters, such as temperature or reaction time. To initiate the reaction, insert the cartridge into the synthesizer, add your starting material, and press START.

          Automatic synthesis: The starting material is prepared (e.g., dissolved), and the solution is then circulated between the vial and the first cartridge compartment for a pre-defined time. Next, it is circulated through a further number of compartments, depending on the reagents required for the reaction.

          Automatic cleaning: After your product is generated, the synthesizer performs automated washing so it’s contamination-free and ready for your next synthesis.

          Unparalleled speed: While manual chemical synthesis can take up to several hours to complete, Synple 2 just requires 5 to 10 minutes of the user’s time.


          Ordering is Just as Simple

          The Synple 2 automated synthesis platform perfectly complements our existing chemistry portfolio, so you have all the products and tools you need from one reliable source. Take advantage of our swift online ordering process, and experience how robotic chemical synthesis will keep your work flowing.


          Synple Cartridges: Choose Your Reaction

          We offer Synple cartridges for eight reaction classes, containing more than 40 different reagents – everything you need for fully automated chemical synthesis. Select a cartridge below to explore its contents, reaction process, and application notes.

          N-Heterocycle Formation (SnAP)

          N-Heterocycle Formation (SnAP)

          Reductive Amination

          Reductive Amination

          Protein Degrader Formation

          Protein Degrader Formation

          Biotin Tags

          Biotin Tags

          Mitsunobu

          Mitsunobu

          Boc Protection

          Boc Protection

          Boc Deprotection

          Boc Deprotection

          Fluorination

          Fluorination


          N-Heterocycle Formation (SnAP)

          What is in the N-Heterocycle Formation Cartridges?

          N-Heterocycle Formation (SnAP)

          N-heterocycle formation cartridges simplify the conversion of a broad range of structurally and electronically diverse aldehydes into N-heterocycles, such as morpholines, piperazines, oxazepanes, and diazepanes, as well as complex spiro and bicyclic structures. They contain all reagents and catalysts needed for imine formation, cyclization, and purification.

          Application Note


          Reaction Process

          Starting Material

          Starting Material

            N-Heterocycle Formation

            Reagent Cartridge: N-Heterocycle Formation

              Synple 2

              Synple 2 Automated Chemical Synthesizer

                N-Heterocycle Scale: 0-0.5 mmol

                Product: N-Heterocycle Scale: 0-0.5 mmol
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                  Reductive Amination

                  What is in the Reductive Amination Cartridges?

                  Reductive Amination - Cartridge contents

                  The reductive amination cartridge facilitates transformation of aldehydes or ketones, and primary or secondary amines into a variety of complex amines. It contains all reagents needed for condensation, reduction, and purification.

                  Application Note


                  Reaction Process

                  Start: Aldehyde/Ketone

                  Starting Material: Aldehyde/Ketone or Amine

                    Reductive Amination

                    Reagent Cartridge: Reductive Amination

                      Synple 2

                      Synple 2 Automated Chemical Synthesizer

                        Product: Amine Scale: 0-0.5 mmol

                        Product: Amine Scale: 0-0.5 mmol
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                          Protein Degrader Formation

                          What is in the Degrader Building Block Formation Cartridges?

                          Protein degrader formation cartridges

                          Protein degrader formation cartridges are designed for PROTAC® synthesis, and are available with either VHL or CRBN ligands in a variety of PEG linker lengths. They contain all reagents needed for linking the aldehyde or ketone group of the protein binder with the protein degrader building block, as well as for purification of the final product.

                          Application Note

                          PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.


                          Reaction Process

                          Starting Material

                          Starting Material

                            Protein Degrader Formation

                            Reagent Cartridge: Protein Degrader Formation

                              Synple 2

                              Synple 2 Automated Chemical Synthesizer

                                Degrader Scale: 0-0.1 mmol

                                Product: Protein Degrader Scale: 0-0.1 mmol
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                                  Biotin Tags

                                  What is in the Biotin Cartridges?

                                  Biotin Diagram

                                  For Amine Linker

                                  Amide Linker Diagram

                                  For Amide Linker

                                  Biotin tag cartridges allow attachment of a range of Biotin tags to either aldehydes and ketones through a reductive amination or amines via acylation. These cartridges are offered with various lengths of PEG linkers. They contain all reagents needed for tagging the compound, as well as for its purification.

                                  Application Note Amine Linker
                                  Application Note Amide Linker


                                  Reaction Process

                                  Start: Aldehyde/Ketone or Amine

                                  Starting Material: Aldehyde/Ketone or Amine

                                    Biotin Tags

                                    Reagent Cartridge: Biotin Tags

                                      Synple 2

                                      Synple 2 Automated Chemical Synthesizer

                                        Biotin Product Scale: 0-0.1 mmol

                                        Biotin-Tagged Product Scale: 0-0.1 mmol
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                                          Mitsunobu

                                          What is in the Mitsunobu Cartridges?

                                          Mitsunobu - Cartridge contents

                                          The Mitsunobu cartridge allows automated reactions to form carbon-carbon bonds through dehydrative coupling of a primary or secondary alcohol with a range of pronucleophiles, such as phenols, phthalimides, tosylamides, and tosylhydrazones. Unlike manual synthesis, there is no risk of by-product formation, thus PPh3O removal is not required.

                                          Application Note


                                          Reaction Process

                                          Start: Alcohol

                                          Starting Material: Alcohol

                                            Mitsunobu

                                            Reagent Cartridge: Mitsunobu

                                              Synple 2

                                              Synple 2 Automated Chemical Synthesizer

                                                Product Scale: 0-0.5 mmol

                                                Product: Amine Scale: 0-0.5 mmol
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                                                  Boc Protection

                                                  What is in the Boc Protection Cartridges?

                                                  Boc Protection Cartridge

                                                  Boc protection cartridges allow fast, automated N-Boc protection of primary and secondary amines, taking just five minutes of work, and leaving no excess Boc-anhydride.

                                                  Application Note


                                                  Reaction Process

                                                  Starting Material: Amine

                                                  Starting Material: Amine

                                                    Boc Protection

                                                    Reagent Cartridge: Boc Protection

                                                      Synple 2

                                                      Synple 2 Automated Chemical Synthesizer

                                                        Boc-Amine Scale: 0-1.2 mmol

                                                        Product: Boc-Protected Amine Scale: 0-1.2 mmol
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                                                          Boc Deprotection

                                                          What is in the Boc Deprotection Cartridges?

                                                          Boc Deprotection Cartridge

                                                          The Boc deprotection cartridge greatly simplifies and accelerates transformation of Boc-protected primary and secondary amines into free amine salts, without exposing users to volatile and corrosive acids, such as TFA, HCI, or TsOH.

                                                          Application Note


                                                          Reaction Process

                                                          Boc-Amine

                                                          Starting Material: Carbamate

                                                            Boc Deprotection

                                                            Reagent Cartridge: Boc Deprotection

                                                              Synple 2

                                                              Synple 2 Automated Chemical Synthesizer

                                                                Free Amine Scale: 0-0.5 mmol

                                                                Product: Free Amine Scale: 0-0.5 mmol
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                                                                  Fluorination

                                                                  What is in the Fluorination Cartridges?

                                                                  Fluorination Cartridge

                                                                  The fluorination (deoxyfluorination) cartridge is optimized for the transformation of primary and secondary alcohols into the corresponding fluorinated product. It enables fast and easy reactions, without exposing users to fluorinating agents as in manual synthesis. It is particularly beneficial for use in pharmaceutical chemistry, especially in late-stage functionalization.

                                                                  Application Note


                                                                  Reaction Process

                                                                  Starting Material: Alcohol

                                                                  Starting Material: Alcohol

                                                                    Fluorination

                                                                    Reagent Cartridge: Fluorination

                                                                      Synple 2

                                                                      Synple 2 Automated Chemical Synthesizer

                                                                        Product Scale: 0-0.5 mmol

                                                                        Fluorinated Product Scale: 0-0.5 mmol

                                                                          Ordering Information

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