HomecollectionsPress ReleasesMilliporeSigma Improves Lab Productivity Through Faster and More Sustainable Nucleic Acid Purification

MilliporeSigma Improves Lab Productivity Through Faster and More Sustainable Nucleic Acid Purification

News Release

  • GenElute™-E Single Spin kits reduce traditional silica-based workflow hands-on time from about 45 minutes to only three minutes
  • Fifty-five percent plastic waste reduction on average through negative chromatography technology
  • Eliminates overnight processing requirements

Burlington, Massachusetts, May 20, 2021 — MilliporeSigma today introduced a new solution improving productivity in the lab through a more flexible and streamlined nucleic acid purification process — GenElute™-E Single Spin purification kits.

“Especially now, when many researchers cannot be in the lab as much or as often as they would like, we want to streamline their efforts on long, manual processes and avoid hazardous liquid waste,” said Klaus-Reinhard Bischoff, head of Research Solutions at MilliporeSigma. “We are proud to offer an exclusive technology that saves time and is more sustainable than usual silica-based options.”

MilliporeSigma‘s new GenElute™-E Single Spin purification kits enable nucleic acid purification without the need for multiple binding and wash steps by separating molecules in the sample by size using negative chromatography technology. Hands-on time is reduced from 45 minutes on average to only three minutes, compared with silica-based kits.

The kit’s application-specific SmartLyse™ enzymes create lysis times of only 10-40 minutes, eliminating overnight processing requirements, which are traditionally required for challenging samples. The new kits reduce lysis and nucleic acid purification steps to under an hour.

Nucleic acid purification, the purification of genomic DNA and RNA, is an essential step in the pursuit of scientific answers to many health-related questions. It is used in virus detection and surveillance, research and therapeutic development, and waste-water testing, and performed before downstream applications such as next-generation sequencing.

MilliporeSigma’s GenElute™-E Single Spin Technology workflow also reduces plastic waste on average by 55 percent, compared with traditional methods, providing a more sustainable alternative and reducing lab waste disposal costs.

About the Life Science Business of Merck KGaA, Darmstadt, Germany

The Life Science business of Merck KGaA, Darmstadt, Germany, which operates as MilliporeSigma in the U.S. and Canada, has some 22,000 employees and 59 manufacturing sites worldwide, with a portfolio of more than 300,000 products focused on scientific discovery, biomanufacturing and testing services. 

Merck KGaA, Darmstadt, Germany, a leading science and technology company, operates across healthcare, life science and performance materials. Around 57,000 employees work to make a positive difference to millions of people’s lives every day by creating more joyful and sustainable ways to live. From advancing gene-editing technologies and discovering unique ways to treat the most challenging diseases to enabling the intelligence of devices – the company is everywhere. In 2019, Merck KGaA, Darmstadt, Germany generated sales of €16.2 billion in 66 countries.

The company holds the global rights to the name and trademark “Merck” internationally. The only exceptions are the United States and Canada, where the business sectors of Merck KGaA, Darmstadt, Germany operate as EMD Serono in healthcare, MilliporeSigma in life science, and EMD Performance Materials. Since its founding 1668, scientific exploration and responsible entrepreneurship have been key to the company’s technological and scientific advances. To this day, the founding family remains the majority owner of the publicly listed company. For more information about Merck, KGaA, Darmstadt, Germany, visit

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