HomeProfessor Product PortalPfaltz Group – Professor Product Portal

Pfaltz Group – Professor Product Portal

Professor Andreas Pfaltz

Andreas Pfaltz has a longstanding interest in the design of chiral ligands for asymmetric catalysis. The semicorrins developed in his group served as the prototype for an important family of nitrogen ligands, the bisoxazolines, which have found widespread use in catalytic asymmetric synthesis. His work on phosphinooxazolines, known as PHOX ligands, has led to numerous efficient chiral transition metal catalysts. Most noteworthy are iridium-PHOX and other N, P ligand complexes, which have greatly enhanced the scope of asymmetric hydrogenation. In contrast to rhodium- or ruthenium-diphosphine complexes, these iridium-based catalysts do not require a coordinating group next to the C=C bond and, therefore, perform well with a wide range of structurally diverse olefins. They have also been successfully used for the hydrogenation of imines and heterocycles such as furans and indoles.

Pfaltz Group Website

Recent papers from the Pfaltz Group

Gani? A, Pfaltz A. 2012. Iridium-Catalyzed Enantioselective Hydrogenation of Alkenylboronic Esters. Chem. Eur. J.. 18(22):6724-6728.
Woodmansee DH, Pfaltz A. 2011. Asymmetric hydrogenation of alkenes lacking coordinating groups. Chem. Commun.. 47(28):7912.
Roseblade SJ, Pfaltz A. 2007. Iridium-Catalyzed Asymmetric Hydrogenation of Olefins. Acc. Chem. Res.. 40(12):1402-1411.
Schumacher A, Bernasconi M, Pfaltz A. 2013. Chiral N-Heterocyclic Carbene/Pyridine Ligands for the Iridium-Catalyzed Asymmetric Hydrogenation of Olefins. Angew. Chem. Int. Ed.. 52(29):7422-7425.
Products available from the Pfaltz Laboratory


  • Organic Synthetic Chemistry
  • Chemical Biology

Professor Product Portal Index

Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?