Chinese Hamster Ovary (CHO) cells are the preferred host for producing therapeutic proteins. However, the development of recombinants is both resource- and time-intensive. Feed combinations developed from EX-CELL® Advanced and Cellvento® technologies improve performance process development by not only decreasing the timeline of selecting high-producing clones but also simplifying the process by single feed at neutral pH reducing contamination risk and cell damage caused by alkaline feed. Together with protein-quality supplements, these technologies reduce resources needed for process development, thereby increasing the number of molecules that can be evaluated concurrently and enabling speed to market.
In this webinar, you will learn:
- Common challenges faced in upstream development
- Benefits of a one-step & neutral pH feed optimization strategy
- Potential application of chemically defined hydrolysates
- Benefits of supplement targeted at adjusting glycosylation attributes
Speaker
Janice Tan, Ph.D.
MilliporeSigma
Head of Upstream MSAT, APAC excluding China
Janice Tan heads the upstream MSAT (manufacturing sciences & technology) team in Asia Pacific, excluding China. She and her team are responsible for providing application and technical consultation on upstream bioprocesses as well as presenting holistic and innovative upstream solutions to customers. Prior to joining, she was involved in developing customized media and feed formulations and applying multi-omics technologies for cell line engineering, media, and process development. Janice received her Ph.D. in biochemistry from the National University of Singapore.
Pharma and biopharma manufacturing
- Viral Vector Upstream Processing
Duration:42min
Language:English
Session 1:presented June 29, 2021
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