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Unlocking Potential Formulation Strategies for Poorly Soluble Molecules



WEBINAR

Poor drug solubility is one of the most inhibiting factors in drug product development. The Developability Classification System (DCS) was developed to assist scientists in optimizing formulations of poorly soluble molecules. Thereby it guides various formulation strategies to overcome solubility issues:

  1. Dissolution enhancement via wetting agents like Poloxamer 188 which accelerate the dissolution profile.
  2. Solid-state modification via solid dispersion technology to enhance fundamentally the solubility. In this context, hot-melt extrusion and spray drying are some of the key technologies to cover a wide range of model APIs: from traditional small to emerging molecules, including the exciting new drug class of PROTACs.

In this webinar, you will learn:

  • Why it is important to distinguish between dissolution and solubility-limited molecules to identify the right formulation strategy
  • How Poloxamers can be used to accelerate dissolution of poorly soluble molecules
  • How solid dispersion technology enhances the solubility and stability of traditional and emerging small molecules (e.g. PROTACs) due to its excellent matrix-forming ability

Speakers

Markus Lubda, Ph.D.

Markus Lubda, Ph.D.

MilliporeSigma

Strategic Marketing Manager

Markus joined MilliporeSigma seven years ago and is a strategic marketing manager, responsible for the development and positioning of an excipient portfolio for oral solid dosage form applications. His focus is on identifying engineered particles to enhance solubility and bioavailability.

He holds a Ph.D. in biology/chemistry from the Technical University of Darmstadt and is a biomolecular engineer.

Rimson Muara Jaya

Rimson Muara Jaya

MilliporeSigma

Customer Application Expert SEATWO

Rimson is a technical application expert, specializing in small to large molecules.  Rimson holds a pharmacist's degree and a master's in business administration. He has more than 10 years of extensive experience in the pharmaceutical industry, with a strong focus on project management, production, and GMP assurance for various small molecule pharmaceutical dosage forms.

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