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BRAF

v-raf murine sarcoma viral oncogene homolog B

Synonyms:
B-RAF1, BRAF1, NS7, RAFB1
Species:
UniProtKB ID:
Gene ID:
  • Human(673) Summary: This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(109880) Braf transforming gene
  • Rat(114486) v-raf murine sarcoma viral oncogene homolog B
  • Horse(100065760) v-raf murine sarcoma viral oncogene homolog B1
  • Zebrafish(403065) v-raf murine sarcoma viral oncogene homolog B1
  • naked mole-rat(101702762) v-raf murine sarcoma viral oncogene homolog B1
  • chicken(396239) v-raf murine sarcoma viral oncogene homolog B1
  • domestic guinea pig(100717765) v-raf murine sarcoma viral oncogene homolog B1
  • dog(475526) v-raf murine sarcoma viral oncogene homolog B1
  • domestic cat(101092346) v-raf murine sarcoma viral oncogene homolog B1
  • cow(536051) v-raf murine sarcoma viral oncogene homolog B
  • sheep(101107438) v-raf murine sarcoma viral oncogene homolog B1

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-B-Raf (pThr753) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
ANTI-BRAF antibody produced in mouse, clone 2F6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
ANTI-BRAF antibody produced in mouse, clone 2F7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
ANTI-BRAF antibody produced in mouse, clone 4G7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
ANTI-BRAF antibody produced in mouse, clone 3F5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot

Cell Lines

Product Number
Description
Species
MCF10A Cells B-RAF V600E, ,
Species
human

Proteins

Product Number
Description
Species
BRAF (416-766), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Braf,
Species
mouse
MISSION® esiRNA, targeting human BRAF,
Species
human