MilliporeSigma

ESR1

estrogen receptor 1

Synonyms:
ER, ESR, ESRA, ESTRR, Era, NR3A1
Species:
UniProtKB ID:
Gene ID:
  • Human(2099) Summary: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]
  • Mouse(13982) estrogen receptor 1 (alpha)
  • Rat(24890) estrogen receptor 1
  • domestic cat(552888) estrogen receptor 1
  • dog(403640) estrogen receptor 1
  • chicken(396099) estrogen receptor 1
  • Thale Cress(837856) ethylene-responsive transcription factor ESR1
  • Horse(791249) estrogen receptor 1
  • Zebrafish(259252) estrogen receptor 1
  • cow(407238) estrogen receptor 1
  • Goat(100860768) estrogen receptor 1
  • sheep(443228) estrogen receptor 1
  • domestic guinea pig(100713276) estrogen receptor 1

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Activator

Product Number
Description
Species
4-Phenylazophenol, 98%,
Species
human
trans-Stilbene, 96%,
Species
human, rat
β-Nicotinamide adenine dinucleotide hydrate, suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Species
human
β-Nicotinamide adenine dinucleotide hydrate, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Species
human
β-Nicotinamide adenine dinucleotide lithium salt from Saccharomyces cerevisiae, ≥95%,
Species
human

Small Molecule - Agonist

Product Number
Description
Species
Estradiol, United States Pharmacopeia (USP) Reference Standard,
Species
human
Estropipate, British Pharmacopoeia (BP) Reference Standard,
Species
human
Estradiol cypionate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Ethinylestradiol for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Dienestrol, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Tamoxifen citrate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Tamoxifen citrate, British Pharmacopoeia (BP) Reference Standard,
Species
human
Tamoxifen citrate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Tamoxifen citrate for performance test, European Pharmacopoeia (EP) Reference Standard,
Species
human
Tamoxifen, analytical standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
2-tert-Butylphenol, 99%,
Species
mouse
3-tert-Butylphenol, 99%,
Species
mouse
Zearalenone, fungal mycotoxin,
Species
mouse
Atrazine, analytical standard,
Species
mouse
2-Chloro-4,6-diamino-1,3,5-triazine, 95%,
Species
mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ESR1, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rabbit
Application
western blot
Anti-phospho-Estrogen Receptor-α (pSer167) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-ESR1 (Ab-106) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-Estrogen Receptor α Antibody, clone F3-A, ascites fluid, clone F3-A, from mouse,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
western blot
ANTI-ESR1 ISOFORM4 (C-TERM) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Biphenyl, ≥99%,
Species
human
Biphenyl, ReagentPlus®, 99.5%,
Species
human
Bicyclohexyl, 99%,
Species
human
4,4′-Dihydroxybiphenyl, 97%,
Species
human
4′-Hydroxy-4-biphenylcarbonitrile, 97%,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Progesterone, VETRANAL®, analytical standard,
Species
human
4-Hydroxyestradiol, ,
Species
rat, human
Tamoxifen, ≥99%,
Species
human, rat
Testosterone, ≥98%,
Species
mouse, human, rat
Progesterone, powder, BioReagent, suitable for cell culture,
Species
mouse, human, rat

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
α-Estradiol, powder, ≥98% (TLC),
Species
human, rat
Medroxyprogesterone 17-acetate, ≥97% (HPLC),
Species
human, rat
Progesterone-Water Soluble, powder, BioReagent, suitable for cell culture,
Species
mouse, human, rat
β-Estradiol, analytical standard,
Species
human, mouse, rat
Estradiol, meets USP testing specifications,
Species
human, mouse, rat

Proteins

Product Number
Description
Species
Estrogen Receptor-α human, ≥80% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ESR1,
Species
human