MilliporeSigma

GSTA2

glutathione S-transferase alpha 2

Synonyms:
GST2, GSTA2-2, GTA2, GTH2
Species:
UniProtKB ID:
Gene ID:
  • Human(2939) Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]
  • Mouse(14858) glutathione S-transferase, alpha 2 (Yc2)
  • Rat(24422) glutathione S-transferase alpha 2
  • cow(281805) glutathione S-transferase alpha 2
  • domestic cat(101096317) glutathione S-transferase alpha 2

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-GSTA2, (N-terminal) antibody produced in mouse, clone 3D4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot

Cell Lines

Product Number
Description
Species
GST A2-2, Recombinant Human, ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GSTA2,
Species
human
MISSION® esiRNA, targeting mouse Gsta2,
Species
mouse